Document Type

Article

Publication Title

Antimicrobial Agents and Chemotherapy

Publication Date

10-2005

Abstract

We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.

DOI

10.1128/AAC.49.10.4354-4357.2005

Included in

Biology Commons

Share

COinS