Document Type

Article

Publication Title

Journal of Bacteriology

Publication Date

4-2000

Abstract

The C-terminal domain of the A subunit of DNA gyrase, which we term Gac, is naturally synthesized in Borrelia burgdorferi as an abundant DNA-binding protein. Full-length GyrA, which includes the C-terminal domain, is also synthesized by the spirochete and functions as a subunit of DNA gyrase, We have disrupted synthesis of Gac as an independent protein and demonstrated that it is not essential for growth in a coumarin-resistant background. We detected no alterations in DNA maintenance, condensation, or topology In B. burgdorferi lacking this small DNA-binding protein.

DOI

10.1128/JB.182.7.2048-2051.2000

Included in

Biology Commons

Share

COinS