Document Type

Article

Publication Title

Journal of Bacteriology

Publisher

American Society for Microbiology

Publication Date

5-1994

Abstract

We have isolated and characterized mutants of Borrelia burgdorferi that are resistant to the antibiotic coumermycin A1, which targets the B subunit of DNA gyrase. Mutants had either 100- or 300-fold higher resistance to coumermycin A1 than wild-type B. burgdorferi. In each case, a single point mutation in the gyrB gene converted Arg-133 to Gly or Ile. Mutations in the homologous Arg residue of Escherichia coli DNA gyrase are also associated with resistance to coumarin antimicrobial agents.

DOI

0021-9193/94

Rights

Copyright © 1994, American Society for Microbiology

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