This collection includes theses, dissertations, and professional papers from the University of Montana Skaggs School of Pharmacy. Theses, dissertations, and professional papers from all University of Montana departments and programs may be searched here.

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Theses/Dissertations from 2017

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MODULATION OF NMDA RECEPTOR-MEDIATED SYNAPTIC TRANSMISSION, Genevieve Elysian Lind

Theses/Dissertations from 2016

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MODULATING MALE AGGRESSION AND COURTSHIP: DETECTING EXTERNAL PHEROMONAL AND NUTRITIONAL INFORMATION, Jonathan C. Andrews

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METHYL-CPG BINDING PROTEINS MEDIATE OCTOPAMINERGIC REGULATION OF COMPLEX BEHAVIORAL TRAITS, Tarun Gupta

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MECHANISMS AND CONSIQENCES OF LYSOSOMAL MEMBRANE PERMEABILIZATION FOLLOWING EXPOSURE TO BIOACTIVE PARTICLES, Forrest Connell Jessop

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DEVELOPMENT OF REPLICATION-COMPETENT VSV-BASED VACCINES FOR PROTECTION AGAINST HANTAVIRUSES, Joshua Ovila Marceau

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SRC FAMILY KINASES MEDIATE INDIVIDUAL CELL RESPONSES TO RECEPTOR TYROSINE KINASE SIGNALING IN NEUROBLASTOMA CELLS, Juan Enrique Palacios Moreno

Theses/Dissertations from 2015

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Lifestyle Effects of Particle Exposure, Traci Ann Brown

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Molecular Modeling Assisted Design and Synthesis of Unsymmetrical Anthracene Isoxazole Small Molecule Anti-tumor Agents, Nathan S. Duncan

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Investigating the Influence of Airborne Particulate Matter Source and Size on Health Outcomes, Matthew Darryl Ferguson

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DNA Methylation in Humans and Dogs: Evaluating the Impact of Nutritional and Particulate Exposures, Luke Benjamin Montrose

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The Regulation of Mucosal Immunity by Inflammatory Mediators, Bryan Joseph Simons

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Methamphetamine and Post-traumatic Epileptogenesis: Investigating the Neuroprotective Effect of Methamphetamine on Post-traumatic Seizures Caused by Traumatic Brain Injury, Debbie Smith

Theses/Dissertations from 2014

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Regulation of silica-induced pulmonary inflammation, Rupa Biswas

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The Role of NADPH Oxidase in the Modulation of PP2A, Nicole M. Byrnes

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Epigenetic Changes after Prenatal Environmental Tobacco Smoke Exposure and Asthma, Sonja Christensen

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CHARACTERIZATION AND KINETIC ANALYSIS OF NOVEL DI-ARYL-SUBSTITUTED ISOXAZOLE HYDRAZONE ANALOGUES AT THE L-CYSTINE/L-GLUTAMATE EXCHANGER SYSTEM XC-, Jayme Lee Hartzell

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An Environmental Toxic Model of Parkinson's Disease: The Fruit Fly, Jennene Lyda

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Interindividual Variability in the Cytochrome P450 3A4 Drug Metabolizing Enzyme: Effect of the CYP3A4*1G Genetic Variant, Kasse Jean Skagen

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The Synthesis and study of heterocyclic, dimeric and chiral ligands for the multidrug-resistance transporter, Scott Steiger

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Glutamate transporter modulation of ambient and synaptic glutamate levels, Weinan Sun

Theses/Dissertations from 2013

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NOVEL G-QUADRUPLEX BINDERS WITH POTENTIAL FOR A DUAL DNA CROSS-LINKING MECHANISM OF ACTION, Nathan S. Duncan

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Activity-based exposure assessments to Libby amphibole associated with public and occupational tasks in the Kootenai National Forest and weatherization of homes containing vermiculite attic insulation, Julie Faroni Hart

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A Molecular Genetic Investigation of the Regulation of Outer Surface Protein C in Borrelia Burgdorferi: Identification and Characterization of the Novel Regulatory Protein BBD18, Beth Hayes

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THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA, Soram Hong

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DIFFERENTIATION-INDUCED CHANGES IN ANTIOXIDANT CAPACITY AND ANTIOXIDANT RESPONSE IN SH-SY5Y CELLS: ROLE OF NRF2, Akua Afriyie Karikari

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MECHANISMS AND CYTOTOXIC EFFECTS OF NQO1-DIRECTED LAVENDAMYCIN DERIVATIVES AND MITOCHONDRIA-TARGETED ANTHRACENYL ISOXAZOLE AMIDES AS NOVEL ANTITUMOR AGENTS, Alison King Kearns

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P-GLYCOPROTEIN TRANSPORT IN PESTICIDE PHARMACOKINETICS AND TOXICITY: INVESTIGATING A LINK TO PARKINSON'S DISEASE RISK, Sarah Elizabeth Lacher

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INDOOR COARSE PARTICULATE MATTER: EVALUATING EXPOSURES AND HEALTH EFFECTS IN ASTHMATIC CHILDREN, Marcy Lynn McNamara

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COMMUNITY-BASED PARTICIPATORY RESEARCH TO PARTNER WITH THE CONFEDERATED SALISH AND KOOTENAI TRIBES IN PHARMACOGENETICS RESEARCH, Chelsea Theresa Morales

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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER, Scott Steiger

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IMPROVED SYNTHESIS OF 3-ARYL-ISOXAZOLES AS INTERMEDIATES FOR NOVEL G-QUADRUPLEX BINDING ANTI-TUMOR AGENTS, Matthew Jacob Weaver

Theses/Dissertations from 2012

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Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease, Jenna Marie Benson

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The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function, Phillip Howard Beske

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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE, Katie Marie Hoffman

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CONSEQUENCES OF ARYL HYDROCARBON RECEPTOR ACTIVATION IN STEADY-STATE AND INFLAMMATORY DENDRITIC CELLS, Thomas Simones

Theses/Dissertations from 2011

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SYNTHESIS OF NB-ARYL-ASPARTAMIDES, Na-ARYLAMIDE-ASPARTATES, AND HYDROXY-L-PROLINE DERIVATIVES AS INHIBITORS OF AMINO ACID TRANSPORT FOR EVALUATING THE GLUTAMINE / GLUTAMATE CYCLE, Brent Russell Lyda

Theses/Dissertations from 2010

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Structure and function of glutamate transporters, David Charles Holley

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THE EFFCT OF LOW-LEVEL LEAD ON SEROTONIN EXPRESSION IN THE DEVELOPING MOUSE SUPERIOR OLIVARY COMPLEX AND SOMATOSENSORY CORTEX, Sunyoung Park

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BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP, TRIDEEP RAJALE

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Phenotype-dependent regulation of the system xC- cystine/glutamate exchanger by glutathione levels in rat astrocyte primary cultures, Todd Seib

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DESIGN, SYNTHESIS AND CHARACTERIZATION OF ISOXAZOLE CONTAINING GLUTAMATE ANALOGS, SHIKHA SHARMA

Theses/Dissertations from 2009

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Consequences of Aryl hydrocarbon receptor activation in dendritic cells, Jaishree Bankoti

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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma, Amy Kay Erbe

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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma, Teri Alyn Girtsman

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PHYSICO-CHEMICAL STUDIES OF THE VESICULAR GLUTAMATE TRANSPORTER 1 (VGLUT1), Jing Guo

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The Influence of SPARC on Collagen Deposition in Asbestos-Induced Pulmonary Fibrosis, Aubrey Meghan Smartt

Theses/Dissertations from 2008

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Novel roles of the endocannabinoid system in modulating synaptic plasticity, Alicia Ninet Angell

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OXIDATIVE STRESS AND THE GUANOSINE NUCLEOTIDE TRIPHOSPHATE POOL: IMPLICATIONS FOR A BIOMARKER AND MECHANISM OF IMPAIRED CELL FUNCTION, Celeste Maree Bolin

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The vesicular glutamate transporter (VGLUT): heterologous expression, proteoliposome, computational and mass spectral studies, Chih-Kai Chao

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Disruption of 8-hydroxy-2'-deoxyguanosine DNA Glycosylase (OGG1) Antioxidant Response Capacity by Sodium Arsenite, David Paul Cox

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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT, Christopher Scott Greil

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Structure Activity Relationships for Intracellular Loop 2 of the 5HT1A Serotonin Receptor, Brian Patrick Hall

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STRUCTURE AND FUNCTION OF A NEURONAL GLUTAMATE TRANSPORTER, Gregory Patrick Leary

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Design, Synthesis and Biological Evaluation of a Family of Excitatory Amino Acid Transporter 3 (EAAT3) Preferring Inhibitors, Terri Lynn Mavencamp

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Chronic low-level Pb exposure during development alters proteins involved in energy metabolism in auditory neurons of the brainstem, John Prins

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Role of scavenger receptor MARCO in particle uptake and lung inflammation, Sheetal A. Thakur

Theses/Dissertations from 2007

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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs), Shailesh Ramjilal Agarwal

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CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX, Tyler John Fortune

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NAD(P)H:QUINONE OXIDOREDUCTASE (NQO1)-DIRECTED LAVENDAMYCIN ANTITUMOR AGENTS: STRUCTURE-BASED DESIGN, MOLECULAR MODELING AND STRUCTURE-ACTIVITY STUDIES, Mary Hassani

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The Role of Silicates in Interstitial Lung Disease, Francisco Jose Leyva

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Role of Sodium Arsenite in Atherogenesis, Flavia Elias Pereira

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The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia, Thomas Fredrick Rau

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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells, Ava-Gaye Tania Rhule

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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter, Wesley Edward Smith

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The role of Zinc and Reactive Oxygen Species in the Regulation of Endothelial Nitric Oxide Synthase, Jason Michael Wilham

Theses/Dissertations from 2006

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Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea, Cherokee Rose Lee Rova

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Genomic analysis of human neuroblastoma cells in response to paraoxon exposure, Matthew D. Thullbery

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The role of excitatory amino acid transporters in neuroprotection and neuropathology, Melodie L. Weller

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The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR, Laura Elizabeth Wilham

Theses/Dissertations from 2005

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Detection of surrogate markers after Gamma-hydroxybutyrate (GHB) exposure, Scott James Larson

Theses/Dissertations from 2004

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Mechanisms of silica exacerbated systemic autoimmune disease in New Zealand mixed mice, Jared Michael Brown

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Regulation of angiogenesis and vascular remodeling by angiogenic factors, Taren Michelle Grass

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Mechanism of arsenic toxicity on vascular development, Wenjie He

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AAV mediated gene delivery to the inner ear an in vitro study, Ida M. Stone

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System xc- pharmacology and its role in beta-L-ODAP pathology and glutathione synthesis, Brady Alan Warren

Theses/Dissertations from 2003

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Mechanisms of action of arsenic-induced cardiovascular disease, Melisa Bunderson

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The role of SHP -1 in deafferentation-induced neuronal death in the murine auditory brainstem, Jie Zhao

Theses/Dissertations from 2002

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Signal transduction and G-protein incorporation properties of human serotonin 1A receptors, Harish Venkat Thiagaraj

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The role of SHP-1 in cerebral ischemia, Celine Ann Wishcamper

Theses/Dissertations from 2001

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Cancer chemoprevention with flavonoids from cereal grains and legume, Lucia Muñiz Alonso

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Distribution of excitatory amino acid transporters (EAATs) in cerebellar granule cell cultures: an immunocytochemical study, Kristen Reed

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Central neurochemical mechanisms involved in the generation of the preovulatory GnRH surge in normally cycling female rats, Daniel John Selvage

Theses/Dissertations from 2000

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Characterisation of high-affinity chloride -dependent L-glutamate transport in glial tumour cells, Sarjubhai Amratbhai Patel

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Immunization against Chlamydia trachomatis infection of the genital tract with antigen -pulsed dendritic cells, Jennifer Hughes Shaw

Theses/Dissertations from 1999

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Identification and characterization of inhibitors of L-glutamate transport into rat brain synaptic vesicles, Richard D. Bartlett

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Cost-shifting among rural Montana independent community pharmacies, Kyle A. Downey

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Structure-activity relationships of the high-affinity glutamate transporters in synaptosomes, Hans-Peter Koch

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Detection of multiple drugs in human hair from seven drug classes using one digestion/extraction protocol, Sarah Kristine Slanger

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Differential effects of triglycerides on in vitro glucose clearance by sheep aortic endothelial and arterial smooth muscle cells, Daniela Vavra

Theses/Dissertations from 1998

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Depression-like behavioral and endocrine effects of brain glucocorticoid type I receptors in the male rat, Bret Fajans Bessac

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Characterization of organotin toxicity in primary astrocyte cultures, Veronica Karpiak

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Effect of cytochrome P-450 1A1 induction on oxidative damage in the brain and liver, Liping Liu

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Synthetic peptide probes of the human 5-HTb1A receptor/G protein interface, Thomas Christian Ortiz

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SHP-1 expression in avian mixed neural/glial cultures, Jeffrey Duane Sorbel

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Differential sensitivity of high-affinity glutamate transport systems to oxidative stress, W. Wallace Webster

Theses/Dissertations from 1997

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Cardioprotection of monophosphoryl lipid A in ischemia and reperfusion-associated injury: Mechanism of action study, Lin Chao

Theses/Dissertations from 1995

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Amino acid carbamates as inhibitors and substrates of high-affinity glutamate transport in rat brain synaptosomes, Colleen A. Baker

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Characteristics of the 5-HTb1A receptor in rabbit brain, John T. Weber

Theses/Dissertations from 1994

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Role of insulin resistance in cardiovascular abnormalities associated with non-insulin-dependent diabetes mellitus, Bernadine Heather Fraser

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The effect of probucol on ethanol induced matrix changes in relationship to cirrhosis of liver, Ravi Gadi