This collection includes theses, dissertations, and professional papers from the University of Montana Skaggs School of Pharmacy. Theses, dissertations, and professional papers from all University of Montana departments and programs may be searched here.
Theses/Dissertations from 2024
EVALUATION OF SILK FIBROIN AND HYLAURONIC ACID AS OTIC DRUG DELIVERY SYSTEM ADDITIVES; INVESTIGATION OF SILK FIBROINS RESPONSES TO ENVIROMENTAL STIMULII, Kolton Charles Sandau
Theses/Dissertations from 2023
SYNTHESIS AND CHARACTERIZATION OF NOVEL BIOMATERIALS: THE USE OF HYALURONAN FOR OTOLOGIC APPLICATIONS AND SILK FIBROIN FOR SENSING APPLICATIONS, Elizabeth Marie Arrigali
Sodium Hyaluronate Based Drug Delivery to the Outer and Inner Ear, Emma Barrett-Catton
Modifying Lysosomal Cholesterol or Potassium Channel Activity Prevents Silica-Induced Inflammation, Rebekah Louise Kendall
TLR4 adjuvanted vaccine against Pseudomonas aeruginosa virulence factor, Pf bacteriophage, induces increased immunoglobulin response and highly mutated antigen-specific B-cell receptors, Valery Cristina Roman-Cruz
Theses/Dissertations from 2022
Development of the novel isoxazolo[3,4-d]pyridazinone scaffold, which positively modulates the metabotropic glutamate receptor subtypes 2 and 4, Christina Ann Gates
EQUITABLE PHARMACOGENETIC TESTING IMPLEMENTATION FOR RURAL AND UNDERSERVED POPULATIONS, Shayna Killam
STRUCTURAL MECHANISM OF NUCLEAR RECEPTOR BIASED AGONISM, Michelle Deanna Nemetchek
Theses/Dissertations from 2021
PULMONARY INNATE LYMPHOCYTES AND AIRWAY INFLAMMATORY RESPONSES TO ALLERGENS AND AIRBORNE PARTICULATES, Maria Martin Ferrini
INVESTIGATIONS ON NOVEL CYP26A1/B1 INHIBITOR, DX308: USING atRA RESPONSE AS A THERAPUTIC TARGET FOR TRAUMATIC BRAIN INJURY AND PARKINSON’S DISEASE, Jacob Morgan Leatherwood
COP9 signalosome component CSN-5 promotes accumulation and function of stem cell regulators FBF-1 and FBF-2, Emily Osterli
SIZE MATTERS: NANOPARTICLES, BIOLOGICAL SEX, AND LUNG DISEASE, Jessica Lynn Ray
USING FORMULATION TO UNLOCK VACCINE ADJUVANT EFFICACY FOR TOLL-LIKE AND C-TYPE LECTIN RECEPTOR AGONSTS, Kristopher Kenneth Short
MECHANISMS OF ENGINEERED NANO-MATERIAL INDUCED MEMBRANE DISRUPTION AND LYSOSOMAL MEMBRANE PERMEABILITY, Matthew Josiah Sydor
Theses/Dissertations from 2020
EPIGENETIC ALTERATIONS IN RESPONSE TO MULTI-WALLED CARBON NANOTUBES AND DHA DIET MODIFICATION, Elizabeth Michelle Cole
INVESTIGATION OF DOCOSAHEXAENOIC ACID AS A POTENTIAL TREATMENT FOR PARTICULATE-INDUCED INFLAMMATION, Paige Lynn Fletcher
THE NMDA RECEPTOR COAGONISTS L-GLUTAMATE AND D-SERINE, Denis Mikhailovich Shchepakin
N-‐HETEROCYCLIC ANTHRYL ISOXAZOLE AMIDES (AIMS) BIND QUADRUPLEX DNA AND EXHIBIT ROBUST ANTITUMOR ACTIVITY, Matthew Jacob Weaver
CONTRIBUTION OF NANOPARTICLE-INDUCED MEMBRANE POTENTIAL ALTERATION IN VARIOUS MODELS OF CELL TOXICITY, Tahereh Ziglari
Theses/Dissertations from 2019
PREVENTION OF CRYSTALLINE SILICA-INDUCED INFLAMMATION BY THE ANTI-MALARIAL HYDROXYCHLOROQUINE, Rachel Dawn Burmeister
NEGATIVE ALLOSTERIC MODULATION OF NMDA RECEPTORS WITH GLUN2A GAIN-OF-FUNCTION MUTATIONS, Jill Christine Farnsworth
NATURAL PRODUCT INDUCTION IN PENCILLIUM AND HUMAN CASPASE CRYSTALLOGRAPHY, kelly j. mcgrath
Avoiding Adverse Effects: New Ideas in Drug Discovery for Targeting PPARγ, Trey M. Patton
Impacts of Trogocytosis-Mediated Intracellular Signaling on CD4+ T cell Effector Cytokine Production and Differentiation, Steven James Reed
MULTINUCLEATED GIANT CELL FORMATION AND PHENOTYPE, Kevin Lewis Trout
CHARACTERIZATION OF NOVEL CYP26B1-INHIBITOR, DX314, FOR THE TREATMENT OF KERATINIZATION DISORDERS, Joachim Gwenn-Stephan Veit
Theses/Dissertations from 2018
A Multifactorial Cytochrome P450 2D6 Genotype-Phenotype Prediction Model to Improve Precision of Clinical Pharmacogenomic Tests, Rachel Dalton
STRUCTURAL CHARACTERIZATION OF THE HUMAN C-MYC QUADRUPLEX AND MECHANISTIC EVALUATION OF ANTITUMOR AGENTS: ANTHRACENYL ISOXAZOLE AMIDES AND QUINOLINEDIONES, Sascha Christian LaMotte Stump
Theses/Dissertations from 2017
The Inflammatory Effects of Natural and Engineered Airborne Particulate Matter in the Lung, and Related Cellular Mechanisms of Immunity, Sophia Tracy Carvalho
MODULATION OF NMDA RECEPTOR-MEDIATED SYNAPTIC TRANSMISSION, Genevieve Elysian Lind
Theses/Dissertations from 2016
MODULATING MALE AGGRESSION AND COURTSHIP: DETECTING EXTERNAL PHEROMONAL AND NUTRITIONAL INFORMATION, Jonathan C. Andrews
METHYL-CPG BINDING PROTEINS MEDIATE OCTOPAMINERGIC REGULATION OF COMPLEX BEHAVIORAL TRAITS, Tarun Gupta
MECHANISMS AND CONSIQENCES OF LYSOSOMAL MEMBRANE PERMEABILIZATION FOLLOWING EXPOSURE TO BIOACTIVE PARTICLES, Forrest Connell Jessop
DEVELOPMENT OF REPLICATION-COMPETENT VSV-BASED VACCINES FOR PROTECTION AGAINST HANTAVIRUSES, Joshua Ovila Marceau
SRC FAMILY KINASES MEDIATE INDIVIDUAL CELL RESPONSES TO RECEPTOR TYROSINE KINASE SIGNALING IN NEUROBLASTOMA CELLS, Juan Enrique Palacios Moreno
Theses/Dissertations from 2015
Lifestyle Effects of Particle Exposure, Traci Ann Brown
Molecular Modeling Assisted Design and Synthesis of Unsymmetrical Anthracene Isoxazole Small Molecule Anti-tumor Agents, Nathan S. Duncan
Investigating the Influence of Airborne Particulate Matter Source and Size on Health Outcomes, Matthew Darryl Ferguson
DNA Methylation in Humans and Dogs: Evaluating the Impact of Nutritional and Particulate Exposures, Luke Benjamin Montrose
The Regulation of Mucosal Immunity by Inflammatory Mediators, Bryan Joseph Simons
Theses/Dissertations from 2014
Regulation of silica-induced pulmonary inflammation, Rupa Biswas
The Role of NADPH Oxidase in the Modulation of PP2A, Nicole M. Byrnes
Epigenetic Changes after Prenatal Environmental Tobacco Smoke Exposure and Asthma, Sonja Christensen
CHARACTERIZATION AND KINETIC ANALYSIS OF NOVEL DI-ARYL-SUBSTITUTED ISOXAZOLE HYDRAZONE ANALOGUES AT THE L-CYSTINE/L-GLUTAMATE EXCHANGER SYSTEM XC-, Jayme Lee Hartzell
An Environmental Toxic Model of Parkinson's Disease: The Fruit Fly, Jennene Lyda
Interindividual Variability in the Cytochrome P450 3A4 Drug Metabolizing Enzyme: Effect of the CYP3A4*1G Genetic Variant, Kasse Jean Skagen
The Synthesis and study of heterocyclic, dimeric and chiral ligands for the multidrug-resistance transporter, Scott Steiger
Glutamate transporter modulation of ambient and synaptic glutamate levels, Weinan Sun
Theses/Dissertations from 2013
NOVEL G-QUADRUPLEX BINDERS WITH POTENTIAL FOR A DUAL DNA CROSS-LINKING MECHANISM OF ACTION, Nathan S. Duncan
DIFFERENTIATION-INDUCED CHANGES IN ANTIOXIDANT CAPACITY AND ANTIOXIDANT RESPONSE IN SH-SY5Y CELLS: ROLE OF NRF2, Akua Afriyie Karikari
MECHANISMS AND CYTOTOXIC EFFECTS OF NQO1-DIRECTED LAVENDAMYCIN DERIVATIVES AND MITOCHONDRIA-TARGETED ANTHRACENYL ISOXAZOLE AMIDES AS NOVEL ANTITUMOR AGENTS, Alison King Kearns
P-GLYCOPROTEIN TRANSPORT IN PESTICIDE PHARMACOKINETICS AND TOXICITY: INVESTIGATING A LINK TO PARKINSON'S DISEASE RISK, Sarah Elizabeth Lacher
INDOOR COARSE PARTICULATE MATTER: EVALUATING EXPOSURES AND HEALTH EFFECTS IN ASTHMATIC CHILDREN, Marcy Lynn McNamara
COMMUNITY-BASED PARTICIPATORY RESEARCH TO PARTNER WITH THE CONFEDERATED SALISH AND KOOTENAI TRIBES IN PHARMACOGENETICS RESEARCH, Chelsea Theresa Morales
4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER, Scott Steiger
IMPROVED SYNTHESIS OF 3-ARYL-ISOXAZOLES AS INTERMEDIATES FOR NOVEL G-QUADRUPLEX BINDING ANTI-TUMOR AGENTS, Matthew Jacob Weaver
Theses/Dissertations from 2012
Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease, Jenna Marie Benson
The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function, Phillip Howard Beske
THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE, Katie Marie Hoffman
CONSEQUENCES OF ARYL HYDROCARBON RECEPTOR ACTIVATION IN STEADY-STATE AND INFLAMMATORY DENDRITIC CELLS, Thomas Simones
Theses/Dissertations from 2011
SYNTHESIS OF NB-ARYL-ASPARTAMIDES, Na-ARYLAMIDE-ASPARTATES, AND HYDROXY-L-PROLINE DERIVATIVES AS INHIBITORS OF AMINO ACID TRANSPORT FOR EVALUATING THE GLUTAMINE / GLUTAMATE CYCLE, Brent Russell Lyda
Theses/Dissertations from 2010
Structure and function of glutamate transporters, David Charles Holley
THE EFFCT OF LOW-LEVEL LEAD ON SEROTONIN EXPRESSION IN THE DEVELOPING MOUSE SUPERIOR OLIVARY COMPLEX AND SOMATOSENSORY CORTEX, Sunyoung Park
BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP, TRIDEEP RAJALE
DESIGN, SYNTHESIS AND CHARACTERIZATION OF ISOXAZOLE CONTAINING GLUTAMATE ANALOGS, SHIKHA SHARMA
Theses/Dissertations from 2009
Consequences of Aryl hydrocarbon receptor activation in dendritic cells, Jaishree Bankoti
The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma, Amy Kay Erbe
Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma, Teri Alyn Girtsman
PHYSICO-CHEMICAL STUDIES OF THE VESICULAR GLUTAMATE TRANSPORTER 1 (VGLUT1), Jing Guo
The Influence of SPARC on Collagen Deposition in Asbestos-Induced Pulmonary Fibrosis, Aubrey Meghan Smartt
Theses/Dissertations from 2008
Novel roles of the endocannabinoid system in modulating synaptic plasticity, Alicia Ninet Angell
OXIDATIVE STRESS AND THE GUANOSINE NUCLEOTIDE TRIPHOSPHATE POOL: IMPLICATIONS FOR A BIOMARKER AND MECHANISM OF IMPAIRED CELL FUNCTION, Celeste Maree Bolin
The vesicular glutamate transporter (VGLUT): heterologous expression, proteoliposome, computational and mass spectral studies, Chih-Kai Chao
Disruption of 8-hydroxy-2'-deoxyguanosine DNA Glycosylase (OGG1) Antioxidant Response Capacity by Sodium Arsenite, David Paul Cox
ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT, Christopher Scott Greil
Structure Activity Relationships for Intracellular Loop 2 of the 5HT1A Serotonin Receptor, Brian Patrick Hall
STRUCTURE AND FUNCTION OF A NEURONAL GLUTAMATE TRANSPORTER, Gregory Patrick Leary
Design, Synthesis and Biological Evaluation of a Family of Excitatory Amino Acid Transporter 3 (EAAT3) Preferring Inhibitors, Terri Lynn Mavencamp
Role of scavenger receptor MARCO in particle uptake and lung inflammation, Sheetal A. Thakur
Theses/Dissertations from 2007
Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs), Shailesh Ramjilal Agarwal
CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX, Tyler John Fortune
The Role of Silicates in Interstitial Lung Disease, Francisco Jose Leyva
Role of Sodium Arsenite in Atherogenesis, Flavia Elias Pereira
The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia, Thomas Fredrick Rau
Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells, Ava-Gaye Tania Rhule
Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter, Wesley Edward Smith
The role of Zinc and Reactive Oxygen Species in the Regulation of Endothelial Nitric Oxide Synthase, Jason Michael Wilham
Theses/Dissertations from 2006
Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea, Cherokee Rose Lee Rova
Genomic analysis of human neuroblastoma cells in response to paraoxon exposure, Matthew D. Thullbery
The role of excitatory amino acid transporters in neuroprotection and neuropathology, Melodie L. Weller
The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR, Laura Elizabeth Wilham
Theses/Dissertations from 2005
Detection of surrogate markers after Gamma-hydroxybutyrate (GHB) exposure, Scott James Larson
Theses/Dissertations from 2004
Mechanisms of silica exacerbated systemic autoimmune disease in New Zealand mixed mice, Jared Michael Brown