Year of Award

2015

Document Type

Dissertation

Degree Type

Doctor of Philosophy (PhD)

Degree Name

Medicinal Chemistry

Department or School/College

Department of Biomedical and Pharmaceutical Sciences

Committee Chair

Nicholas R. Natale

Commitee Members

Howard D. Beall, Donald Stierle, Keith Parker, Orion B. Berryman

Keywords

atropisomer, axial chiral, isoxazole, quadruplex, SNB19

Publisher

The University of Montana

Abstract

There are several isoxazoles in general medical practice and their metabolic fate and disposition is well known, and thus, this heterocyclic ring is often considered among the privileged scaffolds or templates for drug design and discovery. Many examples can be found of 3-aryl-isoxazoles which in theory have a chiral axis, yet actual experimental examples of direct determinations of isoxazole rotational barriers are few and far between. The dihedral angle of the 3-aryl to isoxazole bond in antibacterials of the oxacillin series increased with substitution in the 2- and 6- positions of the phenyl. Although his calculated barrier was low, this implied that atropisomers are possible for unsymmetrical substitution. The chirality of these systems differs from that of other compounds as their configuration is inverted by rotation about single bonds and can be accomplished by thermal equilibration. Thus, depending on the barrier to rotation, some of these atropisomers may only be isolated at low temperatures, if at all.

Available for download on Saturday, September 23, 2017

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© Copyright 2015 Nathan S. Duncan