The Department of Biomedical and Pharmaceutical Sciences at the University of Montana is housed within the Skaggs School of Pharmacy. The Department emphasizes multidisciplinary research, with strengths in molecular pharmacology, toxicology, neurosciences, and medicinal chemistry.

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Submissions from 2019

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MODELING OF EXCITATORY AMINO ACID TRANSPORTERS AND CLEARANCE OF SYNAPTIC CLEFT ON MILLISECOND TIME SCALE, Denis M. Shchepakin, Leonid Kalachev, and Michael Kavanaugh

Submissions from 2016

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D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures, Alan C. Foster, Jill Farnsworth, Genevieve Lind, Yong-Xin Lin, Jia-Ying Yang, Van Dang, Mahmud Penjwini, Veena Viswanath, Ursula Staubli, and Michael Kavanaugh

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MODELING OF AMBIENT GLUTAMATE CONCENTRATION MEASUREMENT IN THE MAMMALIAN NERVOUS SYSTEM, Denis M. Shchepakin, Michael Kavanaugh, and Leonid Kalachev

Submissions from 2015

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Dendritic distributions of lh channels in experimentally-derived multi-compartment models of oriens-lacunosum/moleculare (O-LM) hippocampal interneurons, Vladislav Sekulic, Tse-Chiang Chen, J. Josh Lawrence, and Frances K. Skinner

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Temporal and Spatial Changes in the Pattern of Iba1 and CD68 Staining in the Rat Brain Following Severe Traumatic Brain Injury, Debbie Smith, Diane Brooks, Eric Wohlgehagen, Thomas Rau, and David Poulsen

Submissions from 2014

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Hilar Mossy Cells Provide the First Glutamatergic Synapses to Adult-Born Dentate Granule Cells, Jessica H. Chancey, David J. Poulsen, Jacques I. Wadiche, and Linda Overstreet-Wadiche

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Radiation-induced genomic instability and LINE-1 hypomethylation in radiographers, Yoon Hee Cho

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The Effect of Size on Ag Nanosphere Toxicity in Macrophage Cell Models and Lung Epithelial Cell Lines Is Dependent on Particle Dissolution, Raymond F. Hamilton, Sarah Buckingham, and Andrij Holian

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Synthesis, characterization, and bioactivity of carboxylic acid-functionalized titanium dioxide nanobelts, Raymond F. Hamilton, Nianqiang Wu, Chengcheng Xiang, Ming Li, Feng Yang, Michael Wolfarth, Dale W. Porter, and Andrij Holian

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Assessment of Resident and Faculty Preferences for Clinical Pharmacy Services Within a Developing Family Medicine Residency Program, Kerry Haney

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Phenoxybenzamine Is Neuroprotective in a Rat Model of Severe Traumatic Brain Injury, Thomas Rau, Aakriti Kothiwal, Annela Rova, Joseph F. Rhoderick, and David J. Poulsen

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Using Multi-Compartment Ensemble Modeling as an Investigative Tool of Spatially Distributed Biophysical Balances: Application to Hippocampal Oriens-Lacunosum/Moleculare (O-LM) Cellns, Vladislav Sekulic, J. Josh Lawrence, and Frances K. Skinner

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Household reporting of childhood respiratory health and air pollution in rural Alaska Native communities, Desirae N. Ware, Johnnye Lewis, Scarlett Hopkins, Bert Boyer, Luke Montrose, Curis W. Noonan, Erin O. Semmens, and Tony J. Ward

Submissions from 2013

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Brain immune interactions and air pollution: macrophage inhibitory factor (MIF), prion cellular protein (PrPC), Interleukin-6 (IL-6), interleukin 1 receptor antagonist (IL-1Ra), and interleukin-2 (IL-2) in cerebrospinal fluid and MIF in serum differentiate urban children exposed to severe vs. low air pollution, Lilian Calderón-Garcidueñas, Janet V. Cross, Maricela Franco-Lira, Mariana Aragón-Flores, Michael Kavanaugh, Ricardo Torres-Jardon, Chih-Kai Chao, Charles Thompson, Jing Chang, Hongtu Zhu, and Amedeo D'Angiulli

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Early Alzheimer's and Parkinson's Disease Pathology in Urban Children: Friend versus Foe Responses—It Is Time to Face the Evidence, Lilian Calderón-Garcidueñas, Maricela Franco-Lira, Antonieta Mora-Tiscareño, Humberto Medina-Cortina, Ricardo Torres-Jardon, and Michael Kavanaugh

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Exposure to Urban Air Pollution and Bone Health in Clinically Healthy Six-year-old Children, Lilian Calderón-Garcidueñas, Antonieta Mora-Tiscareño, Maricela Franco-Lira, Ricardo Torres-Jardon, Bernardo Pena-Cruz, Carolina Palacios-López, Hongtu Zhu, Linglong Kong, Nicolas Mendoza-Mendoza, Hortencia Montesinoscorrea, Lina Romero, Gildardo Valencia-Salazar, Michael Kavanaugh, and Silvestre Frenk

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MRI of Neuronal Recovery After Low-Dose Methamphetamine Treatment of Traumatic Brain Injury in Rats, Guang Liang Ding, Michael Chopp, David J. Poulsen, Lian Li, Changsheng Qu, Qingjiang Li, Siamak P. Nejad-Davarani, John S. Budaj, Hongtao Wu, Asim Mahmood, and Quan Jiang

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Analgesic Effect of a Mixed T-Type Channel Inhibitor/CB2 Receptor Agonist, Vinicius M. Gadotti, Haitao You, Ravil R. Petrov, N. Daniel Berger, Philippe Diaz, and Gerald W. Zamponi

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Novel dicarboxylate selectivity in an insect glutamate transporter homolog, Hui Wang, Avi M. Rascoe, David Charles Holley, Eric Gouaux, and Michael Kavanaugh

Submissions from 2012

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Single mutation to a sex pheromone receptor provides adaptive specificity between closely related moth species, Gregory Patrick Leary, Jean E. Allen, Peggy L. Bunger, Jena B. Luginbill, Charles E. Linn Jr., Irene E. Macallister, Michael Kavanaugh, and Kevin W. Wanner

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Oxygen Glucose Deprivation in Rat Hippocampal Slice Cultures Results in Alterations in Carnitine Homeostasis and Mitochondrial Dysfunction, Thomas Rau, Qing Lu, Shruti Sharma, Xutong Sun, Gregory Leary, Matthew L. Beckman, Yal Hou, Mark S. Wainwright, Michael P. Kavanaugh, David J. Poulsen, and Stephen M. Black

Submissions from 2011

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From Good Intentions to Proven Interventions: Effectiveness of Actions to Reduce the Health Impacts of Air Pollution, Luisa V. Giles, Prabjit Barn, Nino Kuenzli, Isabelle Romieu, Murray A. Mittleman, Stephan van Eeden, Ryan Allen, Chris Carlsten, Dave Stieb, Curtis W. Noonan, Audrey Smargiassi, Joel D. Kaufman, Shakoor Hajat, Tom Kosatsky, and Michael Brauer

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The central cavity in trimeric glutamate transporters restricts ligand diffusion, Gregory Patrick Leary, David Charles Holley, Emily F. Stone, Brent Russell Lyda, Leonid Kalachev, and Michael Kavanaugh

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Specificity and Actions of an Arylaspartate Inhibitor of Glutamate Transport at the Schaffer Collateral-Ca1 Pyramidal Cell Synapse, Weinan Sun, Katie M. Hoffman, David C. Holley, and Michael P. Kavanaugh

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Functional Characterization and Analgesic Effects of Mixed Cannabinoid Receptor/T-Type Channel Ligands, Haitao You, Vinicius M. Gadotti, Ravil R. Petrov, Gerald W. Zamponi, and Philippe Diaz

Submissions from 2010

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Organophosphorus Pesticides Decrease M2 Muscarinic Receptor Function in Guinea Pig Airway Nerves Via Indirect Mechanisms, Becky J. Proskocil, Donald A. Bruun, Charles M. Thompson, Allison D. Fryer, and Pamela J. Lein

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Mass Spectrometric Analyses of Organophosphate Insecticide Oxon Protein Adducts, Charles M. Thompson, John M. Prins, and Kathleen M. George

Submissions from 2009

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Assembly of Arenavirus Envelope Glycoprotein Gpc in Detergent-Soluble Membrane Microdomains, Sudhakar S. Agnihothram, Brooke Dancho, Kenneth W. Grant, Mark L. Grimes, Douglas S. Lyles, and Jack H. Nunberg

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Urinary Levoglucosan as a Biomarker of Wood Smoke Exposure: Observations in a Mouse Model and in Children, Christopher T. Migliaccio, M. A. Bergauff, Christopher P. Palmer, Forrest Jessop, Curtis W. Noonan, and Tony Ward

Submissions from 2008

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Neurovirulence of Polytropic Murine Retrovirus Is Influenced by Two Separate Regions on Opposite Sides of the Envelope Protein Receptor Binding Domain, Karin E. Peterson, Susan Pourciau, Min Du, Rachel LaCasse, Melissa Pathmajeyan, David J. Poulsen, Mavis Agbandje-McKenna, Kathy Wehrly, and Bruce Chesebro

Submissions from 2007

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The Glutamate and Chloride Permeation Pathways Are Colocalized in Individual Neuronal Glutamate Transporter Subunits, Gregory Patrick Leary, Emily F. Stone, David Charles Holley, and Michael Kavanaugh

Submissions from 2006

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APPL1 Associates with TrkA and GIPC1 and is Required for Nerve Growth Factor-Mediated Signal Transduction, D. C. Lin, C. Quevedo, N. E. Brewer, A. Bell, J. R. Testa, Mark L. Grimes, F. D. Miller, and D. R. Kaplan

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Nested Case-Control Study of Autoimmune Disease in an Asbestos-Exposed Population, Curis W. Noonan, Jean C. Pfau, Theodore C. Larson, and Michael R. Spence

Submissions from 2005

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Assessment of Autoimmune Responses Associated with Asbestos Exposure in Libby, Montana, USA, Jean C. Pfau, J. J. Sentissi, G. Weller, and Elizabeth Putnam

Submissions from 2004

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Fluorometric measurements of conformational changes in glutamate transporters, H. Peter Larsson, Anastassios V. Tzingounis, Hans-Peter Koch, and Michael Kavanaugh

Submissions from 2003

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Equilibrative Nucleoside Transporter Family Members from Leishmania donovani Are Electrogenic Proton Symporters, Alex Stein, Gayatri Vaseduvan, Nicola S. Carter, Buddy Ullman, Scott M. Landfear, and Michael Kavanaugh

Submissions from 2002

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Dynamic Equilibrium between Coupled and Uncoupled Modes of a Neuronal Glutamate Transporter, Lars Borre, Michael Kavanaugh, and Baruch I. Kanner

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Glutamine Uptake by Neurons: Interaction of Protons with System A Transporters, Farrukh A. Chaudhry, Dietmar Schmitz, Richard J. Reimer, Peter Larsson, Andrew T. Gray, Roger Nicoll, Michael Kavanaugh, and Robert H. Edwards

Submissions from 2001

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Truncated Forms of the Dual Function Human ASCT2 Neutral Amino Acid Transporter/Retroviral Receptor Are Translationally Initiated at Multiple Alternative CUG and GUG Codons, Chetankumar S. Tailor, Mariana Marin, Ali Nouri, Michael Kavanaugh, and David Kabat

Submissions from 2000

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Arginine 447 Plays a Pivotal Role in Substrate Interactions in a Neuronal Glutamate Transporter, Annie Bendahan, Ayelet Armon, Navid Madani, Michael Kavanaugh, and Baruch I. Kanner

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Pentameric assembly of a neuronal glutamate transporter, Sepehr Eskandari, Michael Kreman, Michael Kavanaugh, Ernest M. Wright, and Guido A. Zampighi

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Isolation of Current Components and Partial Reaction Cycles in the Glial Glutamate Transporter EAAT2, Thomas S. Otis and Michael Kavanaugh

Submissions from 1999

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A Critical Site in the Core of the CCR5 Chemokine Receptor Required for Binding and Infectivity of Human Immunodeficiency Virus Type 1, Salvatore J. Siciliano, Shawn E. Kuhmann, Youmin Weng, Navid Madani, Martin S. Springer, Janet E. Lineberger, Renee Danzeisen, Michael D. Miller, Michael Kavanaugh, Julie A. DeMartino, and David Kabat

Submissions from 1998

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Excitatory Amino Acid Transporters of the Salamander Retina: Identification, Localization, and Function, Scott Eliasof, Jeffrey L. Arriza, Barbara H. Leighton, Michael Kavanaugh, and Susan G. Amara

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Neurotransmitter transport: Models in flux, Michael Kavanaugh

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gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5, Navid Madani, Susan L. Kozak, Michael Kavanaugh, and David Kabat

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Arachidonic Acid Activates a Proton Current in the Rat Glutamate Transporter EAAT4, Anastassios V. Tzingounis, Chien-Liang Lin, Jeffrey D. Rothstein, and Michael Kavanaugh

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Macroscopic and Microscopic Properties of a Cloned Glutamate Transporter/Chloride Channel, Jacques I. Wadiche and Michael Kavanaugh

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Cysteine Scanning of the Surroundings of an Alkali-Ion Binding Site of the Glutamate Transporter GLT-1 Reveals a Conformationally Sensitive Residue, Ruth Zarbiv, Myriam Grunewald, Michael Kavanaugh, and Baruch I. Kanner

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Molecular determinant of ion selectivity of a (Na+ + K+)-coupled rat brain glutamate transporter, Yumin Zhang, Annie Bendahan, Ruth Zarbiv, Michael Kavanaugh, and Baruch I. Kanner

Submissions from 1997

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Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance, Jeffrey L. Arriza, Scott Eliasof, Michael Kavanaugh, and Susan G. Amara

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Tyrosine 140 of the γ-Aminobutyric Acid Transporter GAT-1 Plays a Critical Role in Neurotransmitter Recognition, Yona Bismuth, Michael Kavanaugh, and Baruch I. Kanner

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Mutation of an Amino Acid Residue Influencing Potassium Coupling in the Glutamate Transporter GLT-1 Induces Obligate Exchange, Michael Kavanaugh, Annie Bendahan, Noa Zerangue, Yumin Zhang, and Baruch I. Kanner

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Aspartate 19 and Glutamate 121 Are Critical for Transport Function of the myo-Inositol/H+ symporter from Leishmania donovani, Andreas Seyfang, Michael Kavanaugh, and Scott M. Landfear

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Multiple Ionic Conductances of the Human Dopamine Transporter: The Actions of Dopamine and Psychostimulants, Mark S. Sonders, Si-Jia Zhu, Nancy R. Zahniser, Michael Kavanaugh, and Susan G. Amara

Submissions from 1996

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Kinetics and Stoichiometry of a Proton/myo-Inositol Cotransporter, Elizabeth M. Klamo, Mark E. Drew, Scott M. Landfear, and Michael Kavanaugh

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ASCT-1 Is a Neutral Amino Acid Exchanger with Chloride Channel Activity, Noa Zerangue and Michael Kavanaugh

Submissions from 1995

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A Family of Putative Receptor-Adenylate Cyclases from Leishmania donovani, Marco A. Sanchez, David Zeoli, Elizabeth M. Klamo, Michael Kavanaugh, and Scott M. Landfear

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Constitutive Ion Fluxes and Substrate Binding Domains of Human Glutamate Transporters, Robert J. Vandenberg, Jeffrey L. Arriza, Susan G. Amara, and Michael Kavanaugh

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Differential Modulation of Human Glutamate Transporter Subtypes by Arachidonic Acid, Noa Zerangue, Jeffrey L. Arriza, Susan G. Amara, and Michael Kavanaugh

Submissions from 1994

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Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex, Jeffrey L. Arriza, Wendy A. Fairman, Jacques I. Wadiche, Geoffrey H. Murdoch, Michael Kavanaugh, and Susan G. Amara

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Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters, Michael Kavanaugh, Daniel G. Miller, Weibin Zhang, Wendy Law, Susan L. Kozak, David Kabat, and A. Dusty Miller

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Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family, Michael Kavanaugh, Hao Wang, Zheng Zhang, Weibin Zhang, Yan-Na Wu, Esther Dechant, R. Alan North, and David Kabat

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Functional expression of two glucose transporter isoforms from the parasitic protozoan Leishmania enriettii, Chris K. Langford, Brian M. Little, Michael Kavanaugh, and Scott M. Landfear

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Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus, Daniel G. Miller, Robert H. Edwards, and A. Dusty Miller

Submissions from 1993

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Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family, Jeffrey L. Arriza, Michael Kavanaugh, Wendy A. Fairman, Yan-Na Wu, Geoffrey H. Murdoch, R. Alan North, and Susan G. Amara

Submissions from 1992

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Cooperative interactions among subunits of a voltage-dependent potassium channel. Evidence from expression of concatenated cDNAs, Raymond S. Hurst, Michael Kavanaugh, Jerrel Yakel, John P. Adelman, and R. Alan North

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Electrogenic uptake of gamma-aminobutyric acid by a cloned transporter expressed in Xenopus oocytes, Michael Kavanaugh, Jeffrey L. Arriza, R. Alan North, and Susan G. Amara

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Effects of ecotropic murine retroviruses on the dual-function cell surface receptor/basic amino acid transporter, Hao Wang, Esther Dechant, Michael Kavanaugh, R. Alan North, and David Kabat

Submissions from 1991

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Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels, Michael Kavanaugh, Michael D. Varnum, Peregrine B. Osborne, MacDonald J. Christie, Andreas E. Busch, John P. Adelman, and R. Alan North

Submissions from 1989

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Structure and function of human hemoglobin covalently labeled with periodate-oxidized adenosine triphosphate, Michael Kavanaugh, Max F. Perutz, Giulio Fermi, Daniel T. Shih, and Richard T. Jones

Submissions from 1988

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Identification of the binding subunit of the sigma-type opiate receptor by photoaffinity labeling with 1-(4-azido-2-methyl[6-3H]phenyl)-3-(2-methyl[4,6-3H]phenyl)guanidine, Michael Kavanaugh, Barbara C. Tester, Michael W. Scherz, John F. W. Keana, and Eckard Weber