Antimicrobial Agents and Chemotherapy
Biology | Life Sciences
We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.
Galbraith, Kendal M.; Ng, Amanda C.; Eggers, Betsy J.; Kuchel, Craig R.; Eggers, Christian H.; and Samuels, D. Scott, "parC Mutations in Fluoroquinolone-Resistant Borrelia Burgdorfeti" (2005). Biological Sciences Faculty Publications. 1.