International Journal of Peptides
Hindawi Publishing Corporation
Biology | Immunology and Infectious Disease | Life Sciences
Bartonella bacilliformis is the etiologic agent of Carrion's disease suggest complex adaptations by the bacterium to the human host, with the overall objectives of persistence, maintenance of a reservoir state for vectorial transmission, and immune evasion. These events include a multitude of biochemical and genetic mechanisms involving both bacterial and host proteins. This review focuses on proteins involved in interactions between B. bacilliformis and human host. Some of them (e.g., flagellin, Brps, IalB, FtsZ, Hbp/Pap31, and other outer membrane proteins) are potential protein antigen candidates for a synthetic vaccine.
bartonella bacilliformis, Carrion's disease, Oroya fever, vectorial transmission, immune evasion, host proteins, synthetic vaccine
© 2015 Cesar Henriquez-Camacho et al.
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This work is licensed under a Creative Commons Attribution 4.0 License.
Henriquez-Camocho, Cesar; Ventosilla, Palmira; Minnick, Michael F.; Ruiz, Joaquim; and Maguina, Ciro, "Proteins of Bartonella bacilliformis:Candidates for Vaccine Development" (2015). Biological Sciences Faculty Publications. 416.