Year of Award
Doctor of Philosophy (PhD)
Department or School/College
Department of Biomedical and Pharmaceutical Sciences
Howard Beall, Sarjubhai Patel, Kent Sugden, David Burkhart
University of Montana
Using the structure-activity relationship emerging from previous reports, and guided by pharmacokinetic properties, new AIMs have been prepared with both improved efficacy against human glioblastoma cells and cell permeability as determined by fluorescent confocal microscopy. We present our first unambiguous evidence for telomeric G4-forming oligonucleotide anisotropy by NMR resulting from direct interaction with AIMs, which is consistent with both our G4 melting studies by CD, and our working hypothesis. Finally, we show that AIMs induce apoptosis in SNB-19 cells.
Weaver, Matthew Jacob, "N-‐HETEROCYCLIC ANTHRYL ISOXAZOLE AMIDES (AIMS) BIND QUADRUPLEX DNA AND EXHIBIT ROBUST ANTITUMOR ACTIVITY" (2020). Graduate Student Theses, Dissertations, & Professional Papers. 11633.
© Copyright 2020 Matthew Jacob Weaver