Alternative protein conformations: yeast iso-1-cytochrome c
Research Project Description
This research project focused on conformational changes of cytochrome c, a protein that undergoes a structural change as it transitions from functioning in cellular energy production to apoptosis (programmed cell death).
Bruce Bowler's Lab and Sandy Ross’ Lab in Chemistry & Biochemistry
Stephen Sprang's Lab in the Division of Biological Sciences
Macromolecular X-ray Diffraction Facility supported by the Center for Biomolecular Structure and Dynamics (CBSD)
"Events such as Celebrate Academics provide a great forum for cross-disciplinary engagement and sharing of ongoing scholarship campus-wide. Presenting my research on conformational changes of cytochrome c, a protein that undergoes a structural change as it transitions from functioning in cellular energy production to apoptosis (programmed cell death) has been truly exciting. My research project has not only enhanced my development as a researcher through collaboration with multiple labs, it has also provided the opportunity to work closely with other graduate and undergraduate students.
Such collaboration and sharing of knowledge have fostered informative dialogue and new ideas. I recently traveled with my adviser, Bruce Bowler, and several other UM researchers to present at the 58th Annual Biophysical Society Meeting, an international conference held in San Francisco. A manuscript of the work we presented is under review for publication in PNAS (Proceedings of the National Academy of Sciences). As a research institution, UM offers exciting opportunities for collaboration, both locally and nationally."