Title

HEAD-GROUP DEVELOPMENT OF NOREPINEPHRINE AND SEROTONIN SPECIFIC INHIBITORS WITHIN THE HUMAN BRAIN

Presentation Type

Poster

Abstract

The development of piperazine and isoquinoline head groups as precursors were used to create a new class of both serotonin and norepinephrine specific binding proteins which worked with both pain management as well as depression. Compounds must be reacted, purified, and checked through various spectroscopy methods, such as: Mass Spectrometry, NMR, and Thin Plate Chromatography. The methods for synthesis involve many steps of creating a reaction, letting it run, quenching said reaction, doing the work up to rid the reaction of any excess acid/base, and stripping the reaction of solvent on a Roto-vac. These compounds are synthesized as the starting point for exploration into which precursor/ligand combination which will bind most efficiently through analysis of binding assays. This was done in both rat and monkey brains, in preparation for human brain. PET imaging can be used to detect the receptor protein levels in live subjects. This shows real-time results of the synthesized drugs, allowing the question of which is more efficient, to be answered. Currently there is no “Industry standard,” for serotonin specific or norepinephrine specific binding proteins, this development would allow for each to be further synthesized.

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Apr 15th, 3:00 PM Apr 15th, 4:00 PM

HEAD-GROUP DEVELOPMENT OF NOREPINEPHRINE AND SEROTONIN SPECIFIC INHIBITORS WITHIN THE HUMAN BRAIN

UC South Ballroom

The development of piperazine and isoquinoline head groups as precursors were used to create a new class of both serotonin and norepinephrine specific binding proteins which worked with both pain management as well as depression. Compounds must be reacted, purified, and checked through various spectroscopy methods, such as: Mass Spectrometry, NMR, and Thin Plate Chromatography. The methods for synthesis involve many steps of creating a reaction, letting it run, quenching said reaction, doing the work up to rid the reaction of any excess acid/base, and stripping the reaction of solvent on a Roto-vac. These compounds are synthesized as the starting point for exploration into which precursor/ligand combination which will bind most efficiently through analysis of binding assays. This was done in both rat and monkey brains, in preparation for human brain. PET imaging can be used to detect the receptor protein levels in live subjects. This shows real-time results of the synthesized drugs, allowing the question of which is more efficient, to be answered. Currently there is no “Industry standard,” for serotonin specific or norepinephrine specific binding proteins, this development would allow for each to be further synthesized.