Objective: We have found that ~13% of all human genes include at least one exon that can (and apparently does) encode alternate peptides in more than one reading frame. These surprisingly prevalent dual-coding exons are nearly all conserved in the mouse genome, strongly suggesting that they play an important biological role. The objective of this seed grant was to lay the groundwork for a grant proposal to characterize these dual-coding exons, understand when and where they are functional, and learn what sort of sequence and structural traits correlate with their presence.
© 2018 Travis Wheeler
Wheeler, Travis, "Alternative Reading Frames in Protein-coding DNA, a functional and regulatory mystery" (2018). University Grant Program Reports. 43.