Demonstrate feasibility and collect preliminary data to quantify expression of TRPV1 receptors in the nose and throat pre and post BCT in patients with refractory chronic cough (RCC). Minimally invasive brush biopsies, obtained from the nose and larynx will be analyzed using either qPCR for TRPV1 mRNA expression. We propose to analyze both nasal and laryngeal epithelial cells to determine if they respond similarly to behavioral cough therapy (BCT) in patients with RCC. The specific purpose of meeting this aim is to strengthen an R15 or R21 grant proposal that will be submitted within six months of completion of the UGP small grant period.
© 2020 Laurie Slovarp
Slovarp, Laurie, "Investigating the Mechanism Responsible for the Effect of Behavioral Cough Therapy" (2020). University Grant Program Reports. 62.