Document Type
Article
Publication Title
Antimicrobial Agents and Chemotherapy
Publication Date
10-2005
Volume
49
Issue
10
Disciplines
Biology | Life Sciences
Abstract
We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.
DOI
10.1128/AAC.49.10.4354-4357.2005
Recommended Citation
Galbraith, Kendal M.; Ng, Amanda C.; Eggers, Betsy J.; Kuchel, Craig R.; Eggers, Christian H.; and Samuels, D. Scott, "parC Mutations in Fluoroquinolone-Resistant Borrelia Burgdorfeti" (2005). Biological Sciences Faculty Publications. 1.
https://scholarworks.umt.edu/biosci_pubs/1