Resistance of Mice to Infection with Friend Disease Virus After Subcutaneous Injection of Friend Virus and Friend Spleen-Cells

Authors

C. L. LarsonFollow
R. N. Ushijima
S. K. Kasuga
Robert E. Baker, University of Montana - MissoulaFollow
M. B. Baker

Document Type

Article

Publication Title

Infection and Immunity

Publication Date

1973

Volume

8

Issue

5

Disciplines

Biology | Life Sciences

Recommended Citation

Swiss mice injected subcutaneously with suspensions of spleen cells or an extract of spleens from mice infected with Friend virus develop resistance to subsequent intravenous inoculation of Friend virus. A single injection of either Friend virus or Friend cells induces resistance. Immunized mice display resistance when challenged 6 months after immunization and survive for at least 20 weeks after infection. Neutralization tests indicate that serum, but not lymphoid cells of resistant animals, can neutralize Friend virus. In vitro neutralization tests indicate that residence of virus within the peritoneal cavity of immune mice for 1 h sharply reduces the infective titer of the virus.