Structure of maltoheptaose by difference Fourier methods and a model for glycogen

Authors

E. Goldsmith, University of California at San Francisco
S. Sprang, University of MontanaFollow
R. Fletterick, University of California at San Francisco

Document Type

Article

Publication Title

Journal of Molecular Biology

Publication Date

4-5-1982

Volume

156

Issue

2

Disciplines

Biology | Life Sciences

Abstract

The structure of the glucose heptamer, maltoheptaose, has been determined by difference Fourier analysis at 0.25 nm resolution through its binding to phosphorylase a. It is a left-handed helical structure, with 6.5 glucose residues per turn and a rise per residue of 2.4 Å. The molecule shows short-range order when no protein is present to stabilize its conformation in solution. With one exception, the individual torsion angles between sugar residues vary over a narrow range and preserve a good O₍₂₎O_(3′) hydrogen bond. The length of an individual chain for glycogen can be extrapolated from the maltoheptaose data and agrees well with the size for glycogen predicted by the Whelan model.

DOI

https://doi.org/10.1016/0022-2836(82)90336-9

Rights

© 1982 Academic Press Inc. (London) Ltd.

Recommended Citation

Goldsmith, E.; Sprang, S.; and Fletterick, R., "Structure of maltoheptaose by difference Fourier methods and a model for glycogen" (1982). Biological Sciences Faculty Publications. 562.
https://scholarworks.umt.edu/biosci_pubs/562