Presentation Type
Poster Presentation
Category
STEM (science, technology, engineering, mathematics)
Abstract/Artist Statement
This project will develop and introduce novel methods for the separation and analysis of enantiomers. Chiral separation of enantiomers is crucial in the area of drug development where two enantiomers of a compound can have varying effects as pharmaceuticals. Many pharmaceutical compounds or targets are chiral, with each enantiomer producing different biological responses in humans. For this reason, the Food and Drug Administration requires that each enantiomer of a chiral pharmaceutical be isolated and analyzed. Analytical and preparative scale chiral separations are thus critically important.
Chiral compounds have virtually identical chemical and physical properties, meaning separating their enantiomers for analysis is very difficult. Capillary electrophoresis (CE) and electrokinetic chromatographic (EKC) methods utilizing chiral additives have demonstrated significant advantages over conventional methods for analytical scale enantiomer separations. The use of chiral pseudostationary phases in EKC can allow for highly efficient and selective separations of chiral molecules due to stronger interaction of the pseudostationary phase (PSP) with one enantiomer over the other. A chiral polymer of N-Acetyl-Glucosamine generated by controlled polymerization will be characterized and used as the PSP in CE.
Polymeric PSPs have been demonstrated to provide excellent separation performance and compatibility with a broad range of solvent systems and detectors. Chiral additives have been demonstrated to provide rapid and efficient separations of enantiomers by CE. To date, no chiral polymeric PSPs of this type have been investigated for chiral separations in CE.
Implementing a chiral PSP into the background electrolyte of CE for chiral separation and analysis can help ease the drug discovery process where analysis of potential drugs with chiral centers is required. This method would also allow other forms of chiral analysis in chemistry to be done in an easier fashion than previous methods.
Mentor Name
Christopher Palmer
Chiral Nanoparticles for Analysis Using Capillary Electrophoresis
UC North Ballroom
This project will develop and introduce novel methods for the separation and analysis of enantiomers. Chiral separation of enantiomers is crucial in the area of drug development where two enantiomers of a compound can have varying effects as pharmaceuticals. Many pharmaceutical compounds or targets are chiral, with each enantiomer producing different biological responses in humans. For this reason, the Food and Drug Administration requires that each enantiomer of a chiral pharmaceutical be isolated and analyzed. Analytical and preparative scale chiral separations are thus critically important.
Chiral compounds have virtually identical chemical and physical properties, meaning separating their enantiomers for analysis is very difficult. Capillary electrophoresis (CE) and electrokinetic chromatographic (EKC) methods utilizing chiral additives have demonstrated significant advantages over conventional methods for analytical scale enantiomer separations. The use of chiral pseudostationary phases in EKC can allow for highly efficient and selective separations of chiral molecules due to stronger interaction of the pseudostationary phase (PSP) with one enantiomer over the other. A chiral polymer of N-Acetyl-Glucosamine generated by controlled polymerization will be characterized and used as the PSP in CE.
Polymeric PSPs have been demonstrated to provide excellent separation performance and compatibility with a broad range of solvent systems and detectors. Chiral additives have been demonstrated to provide rapid and efficient separations of enantiomers by CE. To date, no chiral polymeric PSPs of this type have been investigated for chiral separations in CE.
Implementing a chiral PSP into the background electrolyte of CE for chiral separation and analysis can help ease the drug discovery process where analysis of potential drugs with chiral centers is required. This method would also allow other forms of chiral analysis in chemistry to be done in an easier fashion than previous methods.