Database for Dynamics: a new approach to model gene regulatory networks

Document Type

Presentation Abstract

Presentation Date

4-11-2016

Abstract

Experimental data on gene regulation is mostly qualitative, where the only information available about pairwise interactions is the presence of either up-or down- regulation. Quantitative data is often subject to large uncertainty and is mostly in terms of fold differences. Given these realities, it is very difficult to make reliable predictions using mathematical models. The current approach of choosing reasonable parameter values, a few initial conditions and then making predictions based on resulting solutions is severely subsampling both the parameter and phase space. This approach does not produce provable and reliable predictions.

We present a new approach that uses continuous time Boolean networks as a platform for qualitative studies of gene regulation. We compute a Database for Dynamics, which rigorously approximates global dynamics over entire parameter space. The results obtained by this method provably capture the dynamics at a predetermined spatial scale.

Additional Details

Monday, April 11, 2016 at 3:10 p.m. in Math 103
Refreshments at 4:00 p.m. in Math Lounge 109

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