The purpose of this UGP proposal was to obtain preliminary data to elucidate the ability of different TLR agonists, alone and in combination with one another and chemotherapy, to induce regression of solid tumors. The specific objectives of this proposal were to: 1) evaluate the ability of a TLR7/8 and/or TLR4 agonist, individually and in combination with one another and the chemotherapy cyclophosphamide, to induce growth arrest or remission of tumors and 2) to dissect the underlying mechanism of action of these compounds on the immune system and in the tumor microenvironment (TME).
© 2018 Alyson Smith
Smith, Alyson, "Investigation of combinatorial innate immunotherapy with chemotherapy to enhance responses in colon cancer" (2018). University Grant Program Reports. 40.