Document Type
Report
Publication Date
9-2025
Abstract
A genetic mutation of MAGED2 protein results in Bartter syndrome, a disease resulting in loss of salt retention, causing premature birth and perinatal mortality. MAGED2 acts upon an important cell signaling protein, Gαs. This proposal investigates the novel interaction between MAGED2 and Gαs. Utilizing Small Angle X-ray Scattering and Macromolecular X-ray Diffraction, we will begin characterizing the structural underpinnings of MAGED2:Gαs, of which there is currently no structure. Additionally, we will characterize the guanine nucleotide exchange activity of MAGED2 upon Gαs. These studies will have implications in treating Bartter syndrome and provide preliminary data for future extramural funding.
Rights
© 2025 Levi McClelland
Recommended Citation
McClelland, Levi J., "A novel G Subunit GEF: MAGED2" (2025). University Grant Program Reports. 88.
https://scholarworks.umt.edu/ugp-reports/88