Presentation Type
Poster
Faculty Mentor’s Full Name
Scott Wetzel
Faculty Mentor’s Department
Immunology / Biological Sciences
Abstract / Artist's Statement
Purpose:
Sepsis frequently manifests as distributive shock and affects several organs, including the heart, which may progress to septic cardiomyopathy (SCM). SCM typically reduces the ejection fraction and causes dilation of the left heart; however, a full understanding of SCM on the right heart is incomplete. Through echocardiography, further qualitative and quantitative alterations in the heart can be identified and guide our clinical management. We aim to identify such alterations in the right ventricle (RV) in patients with SCM through evaluation of serial echocardiography reports.
Methods:
A retrospective cohort study (IRB 20-008691) was conducted on 13,969 sepsis patients hospitalized at the Mayo Clinic Institute between August 2018 and September 2022. Out of 13,969 sepsis patients, 197 septic patients who underwent one pre-sepsis echo and two post-sepsis cardiograms within a year following intensive care unit (ICU) admission were included. The exclusion criteria comprised individuals under 18 years of age, non-ICU patients, and those lacking both pre- and post-sepsis echocardiography records. A sepsis database and electronic medical record reviews were used to extract patient demographics, comorbidities, and outcomes.
Significance:
Our retrospective cohort study observed consistent dysfunctions in the RV throughout the disease course. The results are in line with a study that demonstrated that isolated right ventricular dysfunction was independently linked to worse 1-year survival in septic patients (p=0.002). Similarly, in this study, changes in RV size and function were more apparent in non-survivors in second post-sepsis echos. Thus, patients with RV systolic function changes should be monitored closely, since it is the earliest sign that can be detected in echocardiography. Serial echocardiography is advised in SCM patients to reduce overall morbidity and mortality. Moreover, larger prospective studies are required to study the effect of SCM on the RV in the future, and the further implications of RV dysfunction on patients.
Category
Life Sciences
Assessing the Impact of Septic Cardiomyopathy on the Right Ventricle: A Serial Echocardiogram Study
UC South Ballroom
Purpose:
Sepsis frequently manifests as distributive shock and affects several organs, including the heart, which may progress to septic cardiomyopathy (SCM). SCM typically reduces the ejection fraction and causes dilation of the left heart; however, a full understanding of SCM on the right heart is incomplete. Through echocardiography, further qualitative and quantitative alterations in the heart can be identified and guide our clinical management. We aim to identify such alterations in the right ventricle (RV) in patients with SCM through evaluation of serial echocardiography reports.
Methods:
A retrospective cohort study (IRB 20-008691) was conducted on 13,969 sepsis patients hospitalized at the Mayo Clinic Institute between August 2018 and September 2022. Out of 13,969 sepsis patients, 197 septic patients who underwent one pre-sepsis echo and two post-sepsis cardiograms within a year following intensive care unit (ICU) admission were included. The exclusion criteria comprised individuals under 18 years of age, non-ICU patients, and those lacking both pre- and post-sepsis echocardiography records. A sepsis database and electronic medical record reviews were used to extract patient demographics, comorbidities, and outcomes.
Significance:
Our retrospective cohort study observed consistent dysfunctions in the RV throughout the disease course. The results are in line with a study that demonstrated that isolated right ventricular dysfunction was independently linked to worse 1-year survival in septic patients (p=0.002). Similarly, in this study, changes in RV size and function were more apparent in non-survivors in second post-sepsis echos. Thus, patients with RV systolic function changes should be monitored closely, since it is the earliest sign that can be detected in echocardiography. Serial echocardiography is advised in SCM patients to reduce overall morbidity and mortality. Moreover, larger prospective studies are required to study the effect of SCM on the RV in the future, and the further implications of RV dysfunction on patients.