Presentation Type
Poster
Faculty Mentor’s Full Name
Charles Dumke
Faculty Mentor’s Department
Integrative Physiology and Athletic Training
Abstract / Artist's Statement
THE PHYSIOLOGICAL RESPONSE TO EXERCISE IN POSTMENOPAUSAL WOMEN WITH AND WITHOUT HISTORY OF BREAST CANCER
PURPOSE: Compare the cardiovascular response to acute aerobic exercise in healthy postmenopausal women (HPM) and postmenopausal (PM) women after chemotherapeutic treatment from breast cancer (BPM).
METHODS: 5 PM women with a history of breast cancer and 7 apparently healthy PM women completed two visits to the lab. The first visit consisted of a DEXA scan to measure bone mineral density (BMD) and body composition, and a maximal aerobic capacity test (VO2max) to establish workload. The second visit measured baseline nude body weight (NBW), systolic (SBP) and diastolic (DBP) blood pressure, and blood samples for hematocrit (Hct). Subjects then completed a 30-min steady state exercise bout at 70% of VO2max where measures of VO2, rate of perceived exertion (RPE), and heart rate (HR) were taken every 10 min. Water was prescribed at 3 ml· kg of fat free mass-1·30 min-1. Postexercise, BP was repeated, followed by a 60-min rest. After rest, BP, Hct and NBW were repeated.
SIGNIFICANCE: PM women who have undergone treatment for breast cancer are at an increased risk for cardiovascular disease due to declines in estrogen levels and vascular toxicity from anthracycline and taxane-based chemotherapies. While there is some evidence of the impact of aerobic exercise on vascular function and inflammation in HPM women, there is a paucity of research on the interaction of BC treatment and these physiological responses to exercise. Therefore, the data we obtain from this study will help give a better understanding of this interaction. The results showed no significant differences in age, height, weight, VO2max, body fat, fat free mass, or BMD. HPM demonstrated greater estimated visceral adipose tissue than BPM. Main effect of time was present for RPE, SBP, RER, and NBW. HPM relied more heavily on carbohydrate oxidation than BPM. These early pilot data suggest that despite the toxicity of chemotherapy, there are no significant differences in the cardiovascular responses to acute aerobic exercise between HPM women and BPM. Additionally, BPM had lower visceral fat than the HPM, which has positive cardiometabolic associations. Finally, BPM showed a healthy response to exercise by having a drop in SBP post exercise.
Category
Health and Medical Science (do not choose)
The physiological response to exercise in postmenopausal women with and without a history of breast cancer
UC South Ballroom
THE PHYSIOLOGICAL RESPONSE TO EXERCISE IN POSTMENOPAUSAL WOMEN WITH AND WITHOUT HISTORY OF BREAST CANCER
PURPOSE: Compare the cardiovascular response to acute aerobic exercise in healthy postmenopausal women (HPM) and postmenopausal (PM) women after chemotherapeutic treatment from breast cancer (BPM).
METHODS: 5 PM women with a history of breast cancer and 7 apparently healthy PM women completed two visits to the lab. The first visit consisted of a DEXA scan to measure bone mineral density (BMD) and body composition, and a maximal aerobic capacity test (VO2max) to establish workload. The second visit measured baseline nude body weight (NBW), systolic (SBP) and diastolic (DBP) blood pressure, and blood samples for hematocrit (Hct). Subjects then completed a 30-min steady state exercise bout at 70% of VO2max where measures of VO2, rate of perceived exertion (RPE), and heart rate (HR) were taken every 10 min. Water was prescribed at 3 ml· kg of fat free mass-1·30 min-1. Postexercise, BP was repeated, followed by a 60-min rest. After rest, BP, Hct and NBW were repeated.
SIGNIFICANCE: PM women who have undergone treatment for breast cancer are at an increased risk for cardiovascular disease due to declines in estrogen levels and vascular toxicity from anthracycline and taxane-based chemotherapies. While there is some evidence of the impact of aerobic exercise on vascular function and inflammation in HPM women, there is a paucity of research on the interaction of BC treatment and these physiological responses to exercise. Therefore, the data we obtain from this study will help give a better understanding of this interaction. The results showed no significant differences in age, height, weight, VO2max, body fat, fat free mass, or BMD. HPM demonstrated greater estimated visceral adipose tissue than BPM. Main effect of time was present for RPE, SBP, RER, and NBW. HPM relied more heavily on carbohydrate oxidation than BPM. These early pilot data suggest that despite the toxicity of chemotherapy, there are no significant differences in the cardiovascular responses to acute aerobic exercise between HPM women and BPM. Additionally, BPM had lower visceral fat than the HPM, which has positive cardiometabolic associations. Finally, BPM showed a healthy response to exercise by having a drop in SBP post exercise.