Document Type

Article

Publication Title

Proceedings of the International conference Information Technology and Nanotechnology

Publication Date

2016

Volume

1638

Disciplines

Medical Sciences | Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Abstract

A neuron is an electrically excitable cell that processes and transmits information through electrical and chemical signals. Neurons connect and pass signals to other cells through the structure called synapse. We focus on synapses through which the signals are transferred by signaling molecules called neurotransmitters. One of the predominant excitatory neurotransmitters in the central nervous system of the mammals, including humans, is glutamate. It is directly or indirectly involved in most brain functions. However, the excessive stimulation of the glutamate receptors is toxic to neurons, therefore it is important to rapidly clear the glutamate from the extra-cellular space and keep its concentration low. Glutamate transporters play a crucial role in regulating glutamate concentration in synaptic clefts. Thus, it is important to understand the mechanisms underlying this process. We describe measurement of the glutamate concentration in the extracellular space. It is important to estimate the baseline glutamate concentration to use it in future models and studies. However, two existing methods of measuring the glutamate concentration in the extracellular space give inconsistent results with about 100 fold difference. We construct the model of the process of the glutamate concentration measurement in order to explain that discrepancy.

Keywords

glutamate transport, ambient neurotransmitter, tonic signaling, microdialysis

DOI

10.18287/1613-0073-2016-1638-717-730

Rights

© The Authors

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