Document Type
Article
Publication Title
Journal of Virology
Publication Date
9-2008
Volume
82
Issue
17
Disciplines
Medical Sciences | Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences
Abstract
Changes in the envelope proteins of retroviruses can alter the ability of these viruses to infect the central nervous system (CNS) and induce neurological disease. In the present study, nine envelope residues were found to influence neurovirulence of the Friend murine polytropic retrovirus Fr98. When projected on a three-dimensional model, these residues were clustered in two spatially separated groups, one in variable region B of the receptor binding site and the other on the opposite side of the envelope. Further studies indicated a role for these residues in virus replication in the CNS, although the residues did not affect viral entry.
DOI
10.1128/JVI.02134-07
Recommended Citation
Peterson, Karin E.; Pourciau, Susan; Du, Min; LaCasse, Rachel; Pathmajeyan, Melissa; Poulsen, David J.; Agbandje-McKenna, Mavis; Wehrly, Kathy; and Chesebro, Bruce, "Neurovirulence of Polytropic Murine Retrovirus Is Influenced by Two Separate Regions on Opposite Sides of the Envelope Protein Receptor Binding Domain" (2008). Biomedical and Pharmaceutical Sciences Faculty Publications. 5.
https://scholarworks.umt.edu/biopharm_pubs/5