Title
Identification of a Variant Form of the Human Estrogen Receptor with an Amino Acid Replacement
Document Type
Article
Publication Title
Nucleic Acids Research
Publication Date
1989
Volume
17
Issue
20
Disciplines
Biochemistry | Chemistry | Life Sciences | Physical Sciences and Mathematics
Abstract
Estrogen receptor (ER) is a ligand-dependent transcriptional regulator. ER protein has several functionally distinct regions, including a DNA-binding domain in its midportion, a ligand binding domain in the carboxy terminal region, and at least one domain, in the amino terminal region, that influences the magnitude of transcriptional enhancement (1,2). We now report the sequence of a frequently occurring ER genetic variant that carries two point mutations in the region of the gene encoding the amino terminal domain of the protein.
Rights
© 1989 IRL Press
Recommended Citation
Garcia, T.; Sanchez, M.; Cox, J. L.; Shaw, P. A.; Ross, J. B. A.; Lehrer, S.; and Schachter, B., "Identification of a Variant Form of the Human Estrogen Receptor with an Amino Acid Replacement" (1989). Chemistry and Biochemistry Faculty Publications. 74.
https://scholarworks.umt.edu/chem_pubs/74