This collection includes theses, dissertations, and professional papers from the University of Montana Skaggs School of Pharmacy. Theses, dissertations, and professional papers from all University of Montana departments and programs may be searched here.

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Theses/Dissertations from 2024

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PERSPECTIVES OF UTILIZING PHARMACOGENOMICS TO INFORM TOBACCO CESSATION: SURVEY RESULTS FROM AN AMERICAN INDIAN COMMUNITY, Madeline Lousie Davies

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APPLICATION AND DEVELOPMENT OF CONJUGATION TECHNOLOGY TO ENHANCE THERAPEUTIC INDEX OF TLR7/8 AGONISTS FOR VACCINES, Noah Robert Powers

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EVALUATION OF SILK FIBROIN AND HYLAURONIC ACID AS OTIC DRUG DELIVERY SYSTEM ADDITIVES; INVESTIGATION OF SILK FIBROINS RESPONSES TO ENVIROMENTAL STIMULII, Kolton Charles Sandau

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REGULATION OF ER TO GOLGI TRANSPORT BY ALG-2 AND PEFLIN IN RESPONSE TO CALCIUM SIGNALING, AND A REVIEW OF RELEVANT GENETICALLY-ENCODED FLUORESCENT TOOLS, Danette M. Kowal Seiler

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GENETIC AND ENVIRONMENTAL FACTORS SHAPING PRECISION MEDICINE WITH RURAL AND TRIBAL POPULATIONS IN MONTANA, Jack William Staples

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PERSPECTIVES ON USING PHARMACOGENOMICS TO GUIDE TOBACCO CESSATION: SURVEY RESULTS FROM AN AMERICAN INDIAN COMMUNITY, Daniela Mariana Wall

Theses/Dissertations from 2023

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SYNTHESIS AND CHARACTERIZATION OF NOVEL BIOMATERIALS: THE USE OF HYALURONAN FOR OTOLOGIC APPLICATIONS AND SILK FIBROIN FOR SENSING APPLICATIONS, Elizabeth Marie Arrigali

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Sodium Hyaluronate Based Drug Delivery to the Outer and Inner Ear, Emma Barrett-Catton

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Modifying Lysosomal Cholesterol or Potassium Channel Activity Prevents Silica-Induced Inflammation, Rebekah Louise Kendall

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TLR4 adjuvanted vaccine against Pseudomonas aeruginosa virulence factor, Pf bacteriophage, induces increased immunoglobulin response and highly mutated antigen-specific B-cell receptors, Valery Cristina Roman-Cruz

Theses/Dissertations from 2022

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Development of the novel isoxazolo[3,4-d]pyridazinone scaffold, which positively modulates the metabotropic glutamate receptor subtypes 2 and 4, Christina Ann Gates

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EQUITABLE PHARMACOGENETIC TESTING IMPLEMENTATION FOR RURAL AND UNDERSERVED POPULATIONS, Shayna Killam

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STRUCTURAL MECHANISM OF NUCLEAR RECEPTOR BIASED AGONISM, Michelle Deanna Nemetchek

Theses/Dissertations from 2021

PULMONARY INNATE LYMPHOCYTES AND AIRWAY INFLAMMATORY RESPONSES TO ALLERGENS AND AIRBORNE PARTICULATES, Maria Martin Ferrini

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INVESTIGATIONS ON NOVEL CYP26A1/B1 INHIBITOR, DX308: USING atRA RESPONSE AS A THERAPUTIC TARGET FOR TRAUMATIC BRAIN INJURY AND PARKINSON’S DISEASE, Jacob Morgan Leatherwood

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COP9 signalosome component CSN-5 promotes accumulation and function of stem cell regulators FBF-1 and FBF-2, Emily Osterli

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SIZE MATTERS: NANOPARTICLES, BIOLOGICAL SEX, AND LUNG DISEASE, Jessica Lynn Ray

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USING FORMULATION TO UNLOCK VACCINE ADJUVANT EFFICACY FOR TOLL-LIKE AND C-TYPE LECTIN RECEPTOR AGONSTS, Kristopher Kenneth Short

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MECHANISMS OF ENGINEERED NANO-MATERIAL INDUCED MEMBRANE DISRUPTION AND LYSOSOMAL MEMBRANE PERMEABILITY, Matthew Josiah Sydor

Theses/Dissertations from 2020

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EPIGENETIC ALTERATIONS IN RESPONSE TO MULTI-WALLED CARBON NANOTUBES AND DHA DIET MODIFICATION, Elizabeth Michelle Cole

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INVESTIGATION OF DOCOSAHEXAENOIC ACID AS A POTENTIAL TREATMENT FOR PARTICULATE-INDUCED INFLAMMATION, Paige Lynn Fletcher

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THE NMDA RECEPTOR COAGONISTS L-GLUTAMATE AND D-SERINE, Denis Mikhailovich Shchepakin

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N-­‐HETEROCYCLIC ANTHRYL ISOXAZOLE AMIDES (AIMS) BIND QUADRUPLEX DNA AND EXHIBIT ROBUST ANTITUMOR ACTIVITY, Matthew Jacob Weaver

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CONTRIBUTION OF NANOPARTICLE-INDUCED MEMBRANE POTENTIAL ALTERATION IN VARIOUS MODELS OF CELL TOXICITY, Tahereh Ziglari

Theses/Dissertations from 2019

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PREVENTION OF CRYSTALLINE SILICA-INDUCED INFLAMMATION BY THE ANTI-MALARIAL HYDROXYCHLOROQUINE, Rachel Dawn Burmeister

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NEGATIVE ALLOSTERIC MODULATION OF NMDA RECEPTORS WITH GLUN2A GAIN-OF-FUNCTION MUTATIONS, Jill Christine Farnsworth

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NATURAL PRODUCT INDUCTION IN PENCILLIUM AND HUMAN CASPASE CRYSTALLOGRAPHY, kelly j. mcgrath

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Avoiding Adverse Effects: New Ideas in Drug Discovery for Targeting PPARγ, Trey M. Patton

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Impacts of Trogocytosis-Mediated Intracellular Signaling on CD4+ T cell Effector Cytokine Production and Differentiation, Steven James Reed

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MULTINUCLEATED GIANT CELL FORMATION AND PHENOTYPE, Kevin Lewis Trout

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CHARACTERIZATION OF NOVEL CYP26B1-INHIBITOR, DX314, FOR THE TREATMENT OF KERATINIZATION DISORDERS, Joachim Gwenn-Stephan Veit

Theses/Dissertations from 2018

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A Multifactorial Cytochrome P450 2D6 Genotype-Phenotype Prediction Model to Improve Precision of Clinical Pharmacogenomic Tests, Rachel Dalton

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STRUCTURAL CHARACTERIZATION OF THE HUMAN C-MYC QUADRUPLEX AND MECHANISTIC EVALUATION OF ANTITUMOR AGENTS: ANTHRACENYL ISOXAZOLE AMIDES AND QUINOLINEDIONES, Sascha Christian LaMotte Stump

Theses/Dissertations from 2017

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The Inflammatory Effects of Natural and Engineered Airborne Particulate Matter in the Lung, and Related Cellular Mechanisms of Immunity, Sophia Tracy Carvalho

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MODULATION OF NMDA RECEPTOR-MEDIATED SYNAPTIC TRANSMISSION, Genevieve Elysian Lind

Theses/Dissertations from 2016

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MODULATING MALE AGGRESSION AND COURTSHIP: DETECTING EXTERNAL PHEROMONAL AND NUTRITIONAL INFORMATION, Jonathan C. Andrews

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METHYL-CPG BINDING PROTEINS MEDIATE OCTOPAMINERGIC REGULATION OF COMPLEX BEHAVIORAL TRAITS, Tarun Gupta

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MECHANISMS AND CONSIQENCES OF LYSOSOMAL MEMBRANE PERMEABILIZATION FOLLOWING EXPOSURE TO BIOACTIVE PARTICLES, Forrest Connell Jessop

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DEVELOPMENT OF REPLICATION-COMPETENT VSV-BASED VACCINES FOR PROTECTION AGAINST HANTAVIRUSES, Joshua Ovila Marceau

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SRC FAMILY KINASES MEDIATE INDIVIDUAL CELL RESPONSES TO RECEPTOR TYROSINE KINASE SIGNALING IN NEUROBLASTOMA CELLS, Juan Enrique Palacios Moreno

Theses/Dissertations from 2015

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Lifestyle Effects of Particle Exposure, Traci Ann Brown

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Molecular Modeling Assisted Design and Synthesis of Unsymmetrical Anthracene Isoxazole Small Molecule Anti-tumor Agents, Nathan S. Duncan

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Investigating the Influence of Airborne Particulate Matter Source and Size on Health Outcomes, Matthew Darryl Ferguson

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DNA Methylation in Humans and Dogs: Evaluating the Impact of Nutritional and Particulate Exposures, Luke Benjamin Montrose

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The Regulation of Mucosal Immunity by Inflammatory Mediators, Bryan Joseph Simons

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Methamphetamine and Post-traumatic Epileptogenesis: Investigating the Neuroprotective Effect of Methamphetamine on Post-traumatic Seizures Caused by Traumatic Brain Injury, Debbie Smith

Theses/Dissertations from 2014

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Regulation of silica-induced pulmonary inflammation, Rupa Biswas

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The Role of NADPH Oxidase in the Modulation of PP2A, Nicole M. Byrnes

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Epigenetic Changes after Prenatal Environmental Tobacco Smoke Exposure and Asthma, Sonja Christensen

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CHARACTERIZATION AND KINETIC ANALYSIS OF NOVEL DI-ARYL-SUBSTITUTED ISOXAZOLE HYDRAZONE ANALOGUES AT THE L-CYSTINE/L-GLUTAMATE EXCHANGER SYSTEM XC-, Jayme Lee Hartzell

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An Environmental Toxic Model of Parkinson's Disease: The Fruit Fly, Jennene Lyda

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Interindividual Variability in the Cytochrome P450 3A4 Drug Metabolizing Enzyme: Effect of the CYP3A4*1G Genetic Variant, Kasse Jean Skagen

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The Synthesis and study of heterocyclic, dimeric and chiral ligands for the multidrug-resistance transporter, Scott Steiger

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Glutamate transporter modulation of ambient and synaptic glutamate levels, Weinan Sun

Theses/Dissertations from 2013

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NOVEL G-QUADRUPLEX BINDERS WITH POTENTIAL FOR A DUAL DNA CROSS-LINKING MECHANISM OF ACTION, Nathan S. Duncan

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Activity-based exposure assessments to Libby amphibole associated with public and occupational tasks in the Kootenai National Forest and weatherization of homes containing vermiculite attic insulation, Julie Faroni Hart

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A Molecular Genetic Investigation of the Regulation of Outer Surface Protein C in Borrelia Burgdorferi: Identification and Characterization of the Novel Regulatory Protein BBD18, Beth Hayes

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THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA, Soram Hong

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DIFFERENTIATION-INDUCED CHANGES IN ANTIOXIDANT CAPACITY AND ANTIOXIDANT RESPONSE IN SH-SY5Y CELLS: ROLE OF NRF2, Akua Afriyie Karikari

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MECHANISMS AND CYTOTOXIC EFFECTS OF NQO1-DIRECTED LAVENDAMYCIN DERIVATIVES AND MITOCHONDRIA-TARGETED ANTHRACENYL ISOXAZOLE AMIDES AS NOVEL ANTITUMOR AGENTS, Alison King Kearns

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P-GLYCOPROTEIN TRANSPORT IN PESTICIDE PHARMACOKINETICS AND TOXICITY: INVESTIGATING A LINK TO PARKINSON'S DISEASE RISK, Sarah Elizabeth Lacher

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INDOOR COARSE PARTICULATE MATTER: EVALUATING EXPOSURES AND HEALTH EFFECTS IN ASTHMATIC CHILDREN, Marcy Lynn McNamara

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COMMUNITY-BASED PARTICIPATORY RESEARCH TO PARTNER WITH THE CONFEDERATED SALISH AND KOOTENAI TRIBES IN PHARMACOGENETICS RESEARCH, Chelsea Theresa Morales

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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER, Scott Steiger

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IMPROVED SYNTHESIS OF 3-ARYL-ISOXAZOLES AS INTERMEDIATES FOR NOVEL G-QUADRUPLEX BINDING ANTI-TUMOR AGENTS, Matthew Jacob Weaver

Theses/Dissertations from 2012

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Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease, Jenna Marie Benson

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The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function, Phillip Howard Beske

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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE, Katie Marie Hoffman

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CONSEQUENCES OF ARYL HYDROCARBON RECEPTOR ACTIVATION IN STEADY-STATE AND INFLAMMATORY DENDRITIC CELLS, Thomas Simones

Theses/Dissertations from 2011

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SYNTHESIS OF NB-ARYL-ASPARTAMIDES, Na-ARYLAMIDE-ASPARTATES, AND HYDROXY-L-PROLINE DERIVATIVES AS INHIBITORS OF AMINO ACID TRANSPORT FOR EVALUATING THE GLUTAMINE / GLUTAMATE CYCLE, Brent Russell Lyda

Theses/Dissertations from 2010

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Structure and function of glutamate transporters, David Charles Holley

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THE EFFCT OF LOW-LEVEL LEAD ON SEROTONIN EXPRESSION IN THE DEVELOPING MOUSE SUPERIOR OLIVARY COMPLEX AND SOMATOSENSORY CORTEX, Sunyoung Park

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BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP, TRIDEEP RAJALE

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Phenotype-dependent regulation of the system xC- cystine/glutamate exchanger by glutathione levels in rat astrocyte primary cultures, Todd Seib

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DESIGN, SYNTHESIS AND CHARACTERIZATION OF ISOXAZOLE CONTAINING GLUTAMATE ANALOGS, SHIKHA SHARMA

Theses/Dissertations from 2009

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Consequences of Aryl hydrocarbon receptor activation in dendritic cells, Jaishree Bankoti

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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma, Amy Kay Erbe

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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma, Teri Alyn Girtsman

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PHYSICO-CHEMICAL STUDIES OF THE VESICULAR GLUTAMATE TRANSPORTER 1 (VGLUT1), Jing Guo

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The Influence of SPARC on Collagen Deposition in Asbestos-Induced Pulmonary Fibrosis, Aubrey Meghan Smartt

Theses/Dissertations from 2008

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Novel roles of the endocannabinoid system in modulating synaptic plasticity, Alicia Ninet Angell

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OXIDATIVE STRESS AND THE GUANOSINE NUCLEOTIDE TRIPHOSPHATE POOL: IMPLICATIONS FOR A BIOMARKER AND MECHANISM OF IMPAIRED CELL FUNCTION, Celeste Maree Bolin

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The vesicular glutamate transporter (VGLUT): heterologous expression, proteoliposome, computational and mass spectral studies, Chih-Kai Chao

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Disruption of 8-hydroxy-2'-deoxyguanosine DNA Glycosylase (OGG1) Antioxidant Response Capacity by Sodium Arsenite, David Paul Cox

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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT, Christopher Scott Greil

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Structure Activity Relationships for Intracellular Loop 2 of the 5HT1A Serotonin Receptor, Brian Patrick Hall

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STRUCTURE AND FUNCTION OF A NEURONAL GLUTAMATE TRANSPORTER, Gregory Patrick Leary

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Design, Synthesis and Biological Evaluation of a Family of Excitatory Amino Acid Transporter 3 (EAAT3) Preferring Inhibitors, Terri Lynn Mavencamp

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Chronic low-level Pb exposure during development alters proteins involved in energy metabolism in auditory neurons of the brainstem, John Prins

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Role of scavenger receptor MARCO in particle uptake and lung inflammation, Sheetal A. Thakur

Theses/Dissertations from 2007

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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs), Shailesh Ramjilal Agarwal

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CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX, Tyler John Fortune

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NAD(P)H:QUINONE OXIDOREDUCTASE (NQO1)-DIRECTED LAVENDAMYCIN ANTITUMOR AGENTS: STRUCTURE-BASED DESIGN, MOLECULAR MODELING AND STRUCTURE-ACTIVITY STUDIES, Mary Hassani

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The Role of Silicates in Interstitial Lung Disease, Francisco Jose Leyva

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Role of Sodium Arsenite in Atherogenesis, Flavia Elias Pereira

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The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia, Thomas Fredrick Rau

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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells, Ava-Gaye Tania Rhule

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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter, Wesley Edward Smith

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The role of Zinc and Reactive Oxygen Species in the Regulation of Endothelial Nitric Oxide Synthase, Jason Michael Wilham

Theses/Dissertations from 2006

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Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea, Cherokee Rose Lee Rova