Year of Award
2020
Document Type
Dissertation
Degree Type
Doctor of Philosophy (PhD)
Degree Name
Medicinal Chemistry
Department or School/College
Department of Biomedical and Pharmaceutical Sciences
Committee Chair
Nicholas Natale
Commitee Members
Howard Beall, Sarjubhai Patel, Kent Sugden, David Burkhart
Abstract
Using the structure-activity relationship emerging from previous reports, and guided by pharmacokinetic properties, new AIMs have been prepared with both improved efficacy against human glioblastoma cells and cell permeability as determined by fluorescent confocal microscopy. We present our first unambiguous evidence for telomeric G4-forming oligonucleotide anisotropy by NMR resulting from direct interaction with AIMs, which is consistent with both our G4 melting studies by CD, and our working hypothesis. Finally, we show that AIMs induce apoptosis in SNB-19 cells.
Recommended Citation
Weaver, Matthew Jacob, "N-‐HETEROCYCLIC ANTHRYL ISOXAZOLE AMIDES (AIMS) BIND QUADRUPLEX DNA AND EXHIBIT ROBUST ANTITUMOR ACTIVITY" (2020). Graduate Student Theses, Dissertations, & Professional Papers. 11633.
https://scholarworks.umt.edu/etd/11633
© Copyright 2020 Matthew Jacob Weaver