Synthesis and Biological Evaluation of a Library of Polyacetylene Compounds based on an Antiprotozoal Natural Product from Cussonia zimmermannii

Author

John Hoody, The University of Montana

Year of Award

2014

Document Type

Dissertation

Degree Type

Doctor of Philosophy (PhD)

Degree Name

Chemistry

Department or School/College

Department of Chemistry and Biochemistry

Committee Chair

Christopher P. Palmer

Commitee Members

Holly Thompson, Andrea Stierle, Nigel D. Priestley, Nicholas Natale

Abstract

Leishmaniasis is one of several tropical diseases classified as a ôneglected tropical diseaseö. Its global prevalence is 12 million people with an estimated at-risk population of 350 million people.1 Current treatments include antimonials, amphotericin B, pentamidine, and miltefosine. Access to these medications is often limited in the impoverished nations that Leishmaniasis predominantly affects. Drug resistance and toxicity are also significant drawbacks to the current treatments.3 Therefore, there is an immediate need for the research and development of novel therapeutic molecules and strategies to combat Leishmaniasis.

Recommended Citation

Hoody, John, "Synthesis and Biological Evaluation of a Library of Polyacetylene Compounds based on an Antiprotozoal Natural Product from Cussonia zimmermannii" (2014). Graduate Student Theses, Dissertations, & Professional Papers. 4609.
https://scholarworks.umt.edu/etd/4609