Presentation Type
Oral Presentation
Category
Social Sciences/Humanities
Abstract/Artist Statement
The Advisory Committee on Immunization Practices (ACIP) recommends that children receive multiple routine vaccinations to prevent infectious diseases, with most vaccinations requiring multiple doses. Vaccination series have minimum age and interval requirements, and doses provided outside recommended parameters are considered invalid and should be repeated. Our objective was to quantify the number of U.S. children ages 19-35 months who received invalid vaccination doses, those who had invalid vaccinations re-administered, and factors associated with receiving at least one invalid vaccination.
We analyzed provider-verified vaccination records from the 2011-2020 National Immunization Survey-Child to quantify the number of children with invalid vaccinations and children with corrected doses. A logistic regression model was used to identify demographic or household factors associated with receiving an invalid dose. Analyses accounted for complex survey design, including weighting to represent national estimates.
In analyses of 161,187 children ages 19-35 months old, 23,770 (weighted percent: 16.3%, 95% CI:15.9-16.7%) had at least 1 invalid dose. Vaccination series with the highest number of invalid vaccinations were the 3-dose rotavirus (RV) series (n=5733, 4.4%), 3-dose Haemophilus influenzae type b (Hib) (n=5106, 3.3%), and the 2-dose hepatitis A (HepA) series (n=4192, 2.8%). Of children with invalid vaccinations, 11,297 (48.8%) received extra vaccination doses that corrected the invalid vaccinations and were considered to have completed the vaccination series. Factors associated with receiving at least one invalid vaccination included number of providers, facility type, race/ethnicity, child’s age, geographic mobility, maternal age, and survey year (p-values <0.05).
Our analyses indicate that ~16% of U.S. children have received an invalid vaccination dose, and ~49% of those children have had doses corrected and have received the number of ACIP-recommended vaccination doses for series completion. This work has illuminated the need for future research to evaluate how to reduce the administration of invalid vaccination doses.
Mentor Name
Sophia R Newcomer
Analysis of invalid vaccination dose administration among U.S. children: National Immunization Survey-Child 2011-2020
UC 331
The Advisory Committee on Immunization Practices (ACIP) recommends that children receive multiple routine vaccinations to prevent infectious diseases, with most vaccinations requiring multiple doses. Vaccination series have minimum age and interval requirements, and doses provided outside recommended parameters are considered invalid and should be repeated. Our objective was to quantify the number of U.S. children ages 19-35 months who received invalid vaccination doses, those who had invalid vaccinations re-administered, and factors associated with receiving at least one invalid vaccination.
We analyzed provider-verified vaccination records from the 2011-2020 National Immunization Survey-Child to quantify the number of children with invalid vaccinations and children with corrected doses. A logistic regression model was used to identify demographic or household factors associated with receiving an invalid dose. Analyses accounted for complex survey design, including weighting to represent national estimates.
In analyses of 161,187 children ages 19-35 months old, 23,770 (weighted percent: 16.3%, 95% CI:15.9-16.7%) had at least 1 invalid dose. Vaccination series with the highest number of invalid vaccinations were the 3-dose rotavirus (RV) series (n=5733, 4.4%), 3-dose Haemophilus influenzae type b (Hib) (n=5106, 3.3%), and the 2-dose hepatitis A (HepA) series (n=4192, 2.8%). Of children with invalid vaccinations, 11,297 (48.8%) received extra vaccination doses that corrected the invalid vaccinations and were considered to have completed the vaccination series. Factors associated with receiving at least one invalid vaccination included number of providers, facility type, race/ethnicity, child’s age, geographic mobility, maternal age, and survey year (p-values <0.05).
Our analyses indicate that ~16% of U.S. children have received an invalid vaccination dose, and ~49% of those children have had doses corrected and have received the number of ACIP-recommended vaccination doses for series completion. This work has illuminated the need for future research to evaluate how to reduce the administration of invalid vaccination doses.