Title
Hilar Mossy Cells Provide the First Glutamatergic Synapses to Adult-Born Dentate Granule Cells
Document Type
Article
Publication Title
The Journal of Neuroscience
Publisher
Society for Neuroscience
Publication Date
2-5-2014
Volume
34
Issue
6
Disciplines
Medical Sciences | Medicine and Health Sciences | Molecular and Cellular Neuroscience | Neuroscience and Neurobiology | Pharmacy and Pharmaceutical Sciences
Abstract
Adult-generated granule cells (GCs) in the dentate gyrus must establish synapses with preexisting neurons to participate in network activity. To determine the source of early glutamatergic synapses on newborn GCs in adult mice, we examined synaptic currents at the developmental stage when NMDA receptor-mediated silent synapses are first established. We show that hilar mossy cells provide initial glutamatergic synapses as well as disynaptic GABAergic input to adult-generated dentate GCs.
Keywords
adult neurogenesis, circuit, dentate gyrus, GABA, glutamate, synaptic
DOI
10.1523/JNEUROSCI.3620-13.2014
Rights
© 2014 the authors
Recommended Citation
Chancey, Jessica H.; Poulsen, David J.; Wadiche, Jacques I.; and Overstreet-Wadiche, Linda, "Hilar Mossy Cells Provide the First Glutamatergic Synapses to Adult-Born Dentate Granule Cells" (2014). Biomedical and Pharmaceutical Sciences Faculty Publications. 16.
https://scholarworks.umt.edu/biopharm_pubs/16
Included in
Medical Sciences Commons, Molecular and Cellular Neuroscience Commons, Pharmacy and Pharmaceutical Sciences Commons
Comments
Publisher's Version: http://www.jneurosci.org/content/34/6/2349.short