The Journal of Neuroscience
Society for Neuroscience
Medical Sciences | Medicine and Health Sciences | Molecular and Cellular Neuroscience | Neuroscience and Neurobiology | Pharmacy and Pharmaceutical Sciences
Adult-generated granule cells (GCs) in the dentate gyrus must establish synapses with preexisting neurons to participate in network activity. To determine the source of early glutamatergic synapses on newborn GCs in adult mice, we examined synaptic currents at the developmental stage when NMDA receptor-mediated silent synapses are first established. We show that hilar mossy cells provide initial glutamatergic synapses as well as disynaptic GABAergic input to adult-generated dentate GCs.
adult neurogenesis, circuit, dentate gyrus, GABA, glutamate, synaptic
© 2014 the authors
Chancey, Jessica H.; Poulsen, David J.; Wadiche, Jacques I.; and Overstreet-Wadiche, Linda, "Hilar Mossy Cells Provide the First Glutamatergic Synapses to Adult-Born Dentate Granule Cells" (2014). Biomedical and Pharmaceutical Sciences Faculty Publications. 16.